WormBase Tree Display for Variation: WBVar00146744

WBVar00146744 Evidence: Paper_evidence: WBPaper00005604
  Name: Public_name: h1983
    Other_name: CE26338:p.Asp433Asn
      ZK177.6.2:c.1297G>A
      ZK177.6.1:c.1297G>A
    HGVSg: CHROMOSOME_II:g.5503356G>A
  Sequence_details: SMap: S_parent: Sequence: ZK177
    Flanking_sequences: cgtccgtactctgaaatgctaacagcttct acgatggtttcctgcgtatttaccgattca
    Mapping_target: ZK177
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00005604
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: KR
    Status: Live
  Affects: Gene: WBGene00001511
      WBGene00305941
    Transcript: ZK177.14
      ZK177.6.2 (12)
      ZK177.6.1 (12)
    Interactor: WBInteraction000518319
      WBInteraction000524185
      WBInteraction000537487
  Genetics: Interpolated_map_position: II -1.25733
  Description: Phenotype: WBPhenotype:0000318 Paper_evidence: WBPaper00029006
        Curator_confirmed: WBPerson49113
        Remark: Table 3, duration of cell cycle (in early embryos) from nuclear envelope breakdown (NEBD) to anaphase, and from NEBD to nuclear envelope reformation (NER), was significantly increased in h1983 mutants compared to unc-46(e177) mdf-1(gk2) controls Paper_evidence: WBPaper00029006
            Curator_confirmed: WBPerson49113
        EQ_annotations: Life_stage: WBls:0000004 PATO:0000460 Paper_evidence: WBPaper00029006
                Curator_confirmed: WBPerson49113
        Phenotype_assay: Genotype: unc-46(e177) mdf-1(gk2) Paper_evidence: WBPaper00029006
              Curator_confirmed: WBPerson49113
      WBPhenotype:0000518 Paper_evidence: WBPaper00037616
        Curator_confirmed: WBPerson2784
        Remark: fzy-1(h1983) partially suppresses lethality of mdf-2(tm2190) mutants (Figure 7) Paper_evidence: WBPaper00037616
            Curator_confirmed: WBPerson2784
        Phenotype_assay: Genotype: mdf-2(tm2190) Paper_evidence: WBPaper00037616
              Curator_confirmed: WBPerson2784
      WBPhenotype:0000529 Paper_evidence: WBPaper00037616
        Curator_confirmed: WBPerson2784
        Remark: fzy-1(h1983) rescues mdf-2(tm2190) seam cell defects (Table 3) Paper_evidence: WBPaper00037616
            Curator_confirmed: WBPerson2784
        EQ_annotations: Anatomy_term: WBbt:0005753 PATO:0000460 Paper_evidence: WBPaper00037616
                Curator_confirmed: WBPerson2784
        Phenotype_assay: Genotype: mdf-2(tm2190) Paper_evidence: WBPaper00037616
              Curator_confirmed: WBPerson2784
      WBPhenotype:0001102 Paper_evidence: WBPaper00037650
        Curator_confirmed: WBPerson712
        Remark: Embryos exhibit monopolar spindles and undergo monopolar mitosis. Paper_evidence: WBPaper00037650
            Curator_confirmed: WBPerson712
      WBPhenotype:0001496 Paper_evidence: WBPaper00037650
        Curator_confirmed: WBPerson712
        Remark: Embryos exhibit a minor increase in M phase duration upon bipolar spindle assembly. This effect is highlighted in an spd-5(RNAi) background. Paper_evidence: WBPaper00037650
            Curator_confirmed: WBPerson712
  Reference: WBPaper00037616
    WBPaper00005604
    WBPaper00037650
    WBPaper00029006
  Method: Substitution_allele