Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00145922

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00145922EvidencePaper_evidenceWBPaper00038522
NamePublic_namegk554
Other_nameY73B6BL.21a.1:c.153+60_437del
HGVSgCHROMOSOME_IV:g.6400955_6402215del
Sequence_detailsSMapS_parentSequenceY73B6BL
Flanking_sequencesttagcgggctgcattggttttatacacataatcttcataaattttcacaatttatgcaca
Mapping_targetY73B6BL
Type_of_mutationDeletion
PCR_productgk554_external
gk554_internal
SeqStatusSequenced
Deletion_verificationPCR with one primer internal to the deletion and one external confirms that no WT copy of the gene remains.
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00036420
LaboratoryVC
PersonWBPerson427
KO_consortium_allele
StatusLive
AffectsGeneWBGene00167255
WBGene00168759
WBGene00022242
TranscriptY73B6BL.21d.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
cDNA_position?-275
CDS_position?-275
Protein_position?-92
Intron_number1-2/6
Exon_number1-3/7
Y73B6BL.122
Y73B6BL.148
Y73B6BL.21a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScY73B6BL.21a.1:c.153+60_437del
cDNA_position?-446
CDS_position?-437
Protein_position?-146
Intron_number2-4/9
Exon_number3-5/10
Y73B6BL.21b.1VEP_consequencecoding_sequence_variant,5_prime_UTR_variant
VEP_impactMODIFIER
cDNA_position?-62
CDS_position?-62
Protein_position?-21
Exon_number1/5
Interactor (11)
IsolationMutagenUV/TMP
DescriptionPhenotypeWBPhenotype:0000469Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPerson7575
RemarkThe QL.d localized around their normal positions in sfrp-1 mutants; however, a clear change in the final position of the QR.d was observed, with the QR.d migrating significantly further into the anterior than in wildtype animals.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
In the sfrp-1(gk554) mutant the QR.d overmigrate, whereas the QL.d localize properlyPaper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
EQ_annotationsAnatomy_termWBbt:0004056PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBbt:0004054PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBbt:0008598PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
WBPhenotype:0000471Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPerson7575
RemarkALM exhibits undermigration.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
the sfrp-1(gk554) mutant has undermigrated ALM neuronsPaper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPerson7575
WBPhenotype:0001140Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
Remarksfrp-1 mutants show clear alterations in the Wnt-dependent anteroposterior positioning of migrating neuroblasts. | sfrp-1 mutants show misplacement of the ALM and CAN neurons; the posterior migration of the ALM neurons was significantly truncated. The CAN neurons undermigrated.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0004056PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBbt:0004054PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBbt:0005406PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBbt:0006827PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPhenotype:0001520Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
Remarksfrp-1 mutants show misplacement of the ALM and CAN neurons. In sfrp-1 mutants, the posterior migration of the ALM neurons was significantly truncated. Also, in the case of the CAN neurons, mutation of sfrp-1 induced undermigration.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBbt:0006827PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000062Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
Remarksfrp-1(gk554) is viable and does not induce obvious morphological defects.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPhenotype:0000216Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPerson7575
RemarkThere were no defects in the specification of P12 fate.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
No defect in P12 specificationPaper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
EQ_annotationsAnatomy_termWBbt:0004409PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPerson7575
WBPhenotype:0000470Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
RemarkThere were no defects in the anterior migration of the HSN neurons.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPhenotype:0000520Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
Remarksfrp-1(gk554) does not induce obvious morphological defects.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPhenotype:0000572Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
RemarkNo defects in ALM and PLM polarityPaper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
WBbt:0005490PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
WBPhenotype:0000883Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
RemarkThere were no defects in the positioning of the nerve ring.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPhenotype:0001229Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
RemarkThere were no defects in the polarization of the mechanosensory neurons ALM and PLM.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005490PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPhenotype:0001235Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
RemarkThere were no defects in the polarization of the division of the hypodermal seam cells V5 and T.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005753PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson712
WBPhenotype:0001585Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
RemarkMutants showed no defects in the polarization of the division of the hypodermal seam cells V5 and T.Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
EQ_annotationsAnatomy_termWBbt:0004890PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
WBbt:0004876PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
WBbt:0004946PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
WBbt:0004944PATO:0000460Paper_evidenceWBPaper00038522
Curator_confirmedWBPerson7575
ReferenceWBPaper00038522
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele