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WormBase Tree Display for Variation: WBVar00143997

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Name Class

WBVar00143997NamePublic_namee1423
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004342
LaboratoryCB
StatusLive
AffectsGeneWBGene00001865
GeneticsMapping_dataIn_multi_point111
112
113
In_pos_neg_data5444
5445
5446
5447
DescriptionPhenotypeWBPhenotype:0000050Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Remark78.4% eggs never hatch, yet are refractile; wild type animals produce 0.8% inviable zygotes.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00000179
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals have an average brood size of 4315 s.d. (10 broods counted), wild type has average brood size 33034 s.d. (8 broods counted).Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
low brood size (78% unhatched eggs)Person_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000206Paper_evidenceWBPaper00000179
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkautosomal nondisjunctionPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBls:0000056PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000692Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkmales sire inviable zygotesPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000863Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkMales exhibit 30.3% wild type fertility.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000966Paper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
Remarkgermline is immortal at 20 degrees Celsius, germline mortality only observed at 25 degrees CelsiusPaper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
Phenotype_assayTreatmentStrains propagated for many generations and checked for sterilityPaper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
Temperature25Paper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
WBPhenotype:0001175Paper_evidenceWBPaper00000565
WBPaper00000179
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMale self-progeny make up 16.9% of the population as measured from 20 broods, 1260 total animals.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Animals segregate 15.3% males compared to 0.3% segregated by wild type animals.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
self-progeny 15% XO malePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001583Paper_evidenceWBPaper00000179
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals segregate a small percentage (5.8%) of short animals shown to be 3X hermaphrodites (wild type segregates 0.04% 3X herm.).Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
6% 3X hermPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0001631Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remark8% nullo-X ova as a result of reductional meiotic nondisjunctionPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000143Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentUV sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 1Jm 10X-2/sec. Irradiated animals were protected from light. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000276Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentX-ray sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 470 r/min. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000517Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals are indistinguishable from wild type in terms of behavior.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000520Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkBoth hermaphrodites and males are indistinguishable from wild type in terms of superficial anatomy.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0001631Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkThe sex ratio of cross progeny sired by him males does not significantly differ from 1:1.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Disease_infoModels_diseaseDOID:2717
Models_disease_in_annotationWBDOannot00000436
WBDOannot00000437
Reference (11)
MethodAllele