WormBase Tree Display for Variation: WBVar00143962

WBVar00143962 Evidence: Paper_evidence: WBPaper00035610
  Name: Public_name: e1385
    Other_name: W01G7.1.2:c.1264C>T
      W01G7.1.1:c.1264C>T
      CE18985:p.Gln422Ter
    HGVSg: CHROMOSOME_II:g.14035095G>A
  Sequence_details: SMap: S_parent: Sequence: W01G7
    Flanking_sequences: gagtccgatttcacacataaagtcgtcacg agcagcaagaatggaaggcaaagatgaagg
    Mapping_target: W01G7
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004316
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00000901
    Transcript: W01G7.1.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: W01G7.1.1:c.1264C>T
        HGVSp: CE18985:p.Gln422Ter
        cDNA_position: 1271
        CDS_position: 1264
        Protein_position: 422
        Exon_number: 5/7
        Codon_change: Cag/Tag
        Amino_acid_change: Q/*
      W01G7.1.2 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: W01G7.1.2:c.1264C>T
        HGVSp: CE18985:p.Gln422Ter
        cDNA_position: 1408
        CDS_position: 1264
        Protein_position: 422
        Exon_number: 6/8
        Codon_change: Cag/Tag
        Amino_acid_change: Q/*
    Interactor: WBInteraction000518711
      WBInteraction000536045
      WBInteraction000536049
      WBInteraction000536054
      WBInteraction000536057
  Genetics: Interpolated_map_position: II 22.3112
  Description: Phenotype: WBPhenotype:0001090 Paper_evidence: WBPaper00038374
        Curator_confirmed: WBPerson2987
        Remark: "A mutation in daf-5 also significantly reduces thermotolerance of daf-2(e1370) worms at 37C (Figure S13)." Paper_evidence: WBPaper00038374
            Curator_confirmed: WBPerson2987
          Figure S13C Paper_evidence: WBPaper00038374
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: daf-2(e1370) Paper_evidence: WBPaper00038374
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001171 Paper_evidence: WBPaper00038374
        Curator_confirmed: WBPerson2987
        Remark: "A mutation in daf-5 also decreased the increased lifespan of age-1(hx546) worms, with age-1(hx546); daf-5(e1385) double mutants living significantly shorter than the parental strain (Figure S13)." Paper_evidence: WBPaper00038374
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: age-1(hx546) Paper_evidence: WBPaper00038374
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001183 Paper_evidence: WBPaper00038374
        Curator_confirmed: WBPerson2987
        Remark: "Similarly, age-1(hx546); daf-5(e1385) had less fat than age-1(hx546) worms (Figure S12)." Paper_evidence: WBPaper00038374
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: age-1(hx546) Paper_evidence: WBPaper00038374
              Curator_confirmed: WBPerson2987
    Phenotype_not_observed: WBPhenotype:0000717 Paper_evidence: WBPaper00035610
        Curator_confirmed: WBPerson2021
        Remark: In daf-5 mutants, there were no significant changes in the expression of the daf genes tested Paper_evidence: WBPaper00035610
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: qRT-PCR Paper_evidence: WBPaper00035610
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000823 Paper_evidence: WBPaper00035610
        Curator_confirmed: WBPerson2021
        Remark: The mitotic region of daf-5(e1385) was indistinguishable from that of the wild type Paper_evidence: WBPaper00035610
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: DAPI staining Paper_evidence: WBPaper00035610
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00038374
    WBPaper00035610
  Method: Substitution_allele