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WormBase Tree Display for Variation: WBVar00143773

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Name Class

WBVar00143773EvidencePerson_evidenceWBPerson384
NamePublic_namee1141
Other_namee1114Person_evidenceWBPerson384
CE05795:p.Thr66Ile
F32G8.6.1:c.197C>T
HGVSgCHROMOSOME_V:g.10565677C>T
Sequence_detailsSMapS_parentSequenceF32G8
Flanking_sequencescaggagaagacatcaatcgtcagggacttctgaaaatccagaacgtgctgccaaagcaatgatggcattcac
Mapping_targetF32G8
Type_of_mutationSubstitutionct
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004253
WBStrain00004816
WBStrain00027351
LaboratoryCB
StatusLive
AffectsGeneWBGene00000298
TranscriptF32G8.6.1 (12)
InteractorWBInteraction000500584
WBInteraction000555810
GeneticsInterpolated_map_positionV2.59941
Mapping_dataIn_multi_point151
1529
2269
In_pos_neg_data6765
6766
6767
6769
6771
DescriptionPhenotypeWBPhenotype:0000164Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000201Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkcuticle defectivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000224Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkserotonin reduced or absent; suppressed by serotonin agonists; serotonin immunoreactivity restored by exogenous serotonin or 5-hydroxytryptophan; cuticle defective,Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004929Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000227Paper_evidenceWBPaper00001861
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMore defective than cat-1 males, with frequent sloppy and missed turns, ~30% good turns. No males were perfect, e.g. made good turns 100% of the time. Turning ability was restored with exposure to 1mM serotonin for 1 hourPaper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
poor male turning behaviorPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0000233Paper_evidenceWBPaper00000365
Curator_confirmedWBPerson712
RemarkDopamine levels are severely reduced.Paper_evidenceWBPaper00000365
Curator_confirmedWBPerson712
WBPhenotype:0000234Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkdopamine reduced > 90%Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004583Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000237Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkenhanced foraging behaviorPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000324Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000424Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
RemarkComplete lack of serotonin-IR(immunoreactivity), can be restored by treatment with serotonin or its precursor, 5-HTP.Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0000425Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
RemarkSerotonin levels are reduced in HSNs and 8 other serotonergic head neurons (determined immunocytochemically)Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006837PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBbt:0006830PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
Life_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0000648Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
RemarkMutant males seem to be unable to track the hermaphrodite after contact, lose contact altogether, have difficulty escaping from spontaneous dorsal inward tail coils, and are more likely to ignore contact with a hermaphrodite.Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0001066Paper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
RemarkThe duration of the inactive phase was substantially longer in the cat-4 mutants than in wild-type animalsPaper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
WBPhenotype:0001444Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals exhibited defective gustatory plasticity of NaCl.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested for response to 25 mM NaCl after various pre-treatments: a 15-min wash in CTX buffer with or without 100 mM NaCl (liquid), or 30 min on a CTX plate with or without 100 mM NaCl, and in the presence or absence of bacteria, 500 mM glycerol, or 3 uL of benzaldehyde.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
WBPhenotype:0001518Paper_evidenceWBPaper00000365
Curator_confirmedWBPerson712
RemarkFormaldehyde induced fluorescence is (FIF) is generally reduced by faintly visible in some animals.Paper_evidenceWBPaper00000365
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00000365
Curator_confirmedWBPerson712
WBPhenotype:0001918Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkhypersensitive to SDS, levamisole, hypochloritePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003977Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBMol:00004019Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBMol:00002895Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0002286Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002288Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002295Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002303Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002312Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002318Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002319Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002322Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002325Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002336Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002344Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002346Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002348Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000456Paper_evidenceWBPaper00000365
Curator_confirmedWBPerson712
WBPhenotype:0000525Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0001206Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0001765Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
RemarkMutants defective in the synthesis and reception of nonessential excitatory neurotransmitters respond normally to CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatment10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
WBPhenotype:0001780Paper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
RemarkMutants show normal butanone enhancementPaper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentPreexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assaysPaper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
Reference (17)
MethodSubstitution_allele