WormBase Tree Display for Variation: WBVar00143733

WBVar00143733 Name: Public_name: e1091
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (34)
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00006752
    Interactor: WBInteraction000518152
      WBInteraction000555944
  Genetics: Mapping_data: In_2_point: 204
        737
        2513
        6044
        6118
      In_multi_point (25)
      In_pos_neg_data (11)
  Description: Phenotype: WBPhenotype:0000054 Paper_evidence: WBPaper00032269
        Curator_confirmed: WBPerson712
        Penetrance: Low: Paper_evidence: WBPaper00032269
              Curator_confirmed: WBPerson712
      WBPhenotype:0000153 Paper_evidence: WBPaper00032190
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited increased contractions. Paper_evidence: WBPaper00032190
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: zxIs6 Paper_evidence: WBPaper00032190
              Curator_confirmed: WBPerson712
      WBPhenotype:0001316 Paper_evidence: WBPaper00032190
        Curator_confirmed: WBPerson712
        Remark: ACh photo-ePSCs were drastically reduced, even during repeated stimulation. Paper_evidence: WBPaper00032190
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: zxIs6 Paper_evidence: WBPaper00032190
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000306 Paper_evidence: WBPaper00032190
        Curator_confirmed: WBPerson712
        Remark: Expression of ChR2-YFP in cholinergic neurons was not affected. Paper_evidence: WBPaper00032190
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: zxIs6 Paper_evidence: WBPaper00032190
              Curator_confirmed: WBPerson712
      WBPhenotype:0001278 Paper_evidence: WBPaper00050142
        Curator_confirmed: WBPerson2987
        Remark: "In contrast, mutations that block small molecule neurosecretion, unc-13(e1091) or unc-18(e81), had no effect on the mitochondrial stress response to polyQ40 expression in the nervous system (Figure 4A)." Paper_evidence: WBPaper00050142
            Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0034514 PATO:0000460 Paper_evidence: WBPaper00050142
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: rmIs101 [rgef-1p::Q40::YFP]; zcIs13 [hsp-6p::GFP] Paper_evidence: WBPaper00050142
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001285 Paper_evidence: WBPaper00045598
        Curator_confirmed: WBPerson712
        Remark: Exposure of mutant strains to 10% CO2 showed pumping behavior similar to that of wild-type strains. Paper_evidence: WBPaper00045598
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003023 Paper_evidence: WBPaper00045598
              Curator_confirmed: WBPerson712
      WBPhenotype:0001426 Paper_evidence: WBPaper00004883
        Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: arIs37 Paper_evidence: WBPaper00004883
              Curator_confirmed: WBPerson712
      WBPhenotype:0001800 Paper_evidence: WBPaper00033094
        Curator_confirmed: WBPerson2021
        Remark: Normal increase in pnlp-29::GFP expression after infection. Paper_evidence: WBPaper00033094
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00033094
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: frIs7 [pnlp-29::GFP] Paper_evidence: WBPaper00033094
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001838 Paper_evidence: WBPaper00033094
        Curator_confirmed: WBPerson2021
        Remark: The PMA-induced upregulation of pnlp-29::GFP expression was normal in mutant worms Paper_evidence: WBPaper00033094
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00033094
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: frIs7 [pnlp-29::GFP] Paper_evidence: WBPaper00033094
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001840 Paper_evidence: WBPaper00033094
        Curator_confirmed: WBPerson2021
        Remark: Normal increase in pnlp-29::GFP expression after wounding Paper_evidence: WBPaper00033094
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00033094
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: frIs7 [pnlp-29::GFP] Paper_evidence: WBPaper00033094
              Curator_confirmed: WBPerson2021
  Reference (20)
  Remark
  Method: Allele