WormBase Tree Display for Variation: WBVar00143733
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| WBVar00143733 | Name | Public_name | e1091 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sequence_details | SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00000044 | ||||||||
| WBStrain00003962 | |||||||||
| WBStrain00003973 | |||||||||
| WBStrain00004242 | |||||||||
| WBStrain00004373 | |||||||||
| WBStrain00007274 | |||||||||
| WBStrain00007278 | |||||||||
| WBStrain00007279 | |||||||||
| WBStrain00007280 | |||||||||
| WBStrain00007281 | |||||||||
| WBStrain00007282 | |||||||||
| WBStrain00008444 | |||||||||
| WBStrain00022550 | |||||||||
| WBStrain00022559 | |||||||||
| WBStrain00022560 | |||||||||
| WBStrain00022561 | |||||||||
| WBStrain00022562 | |||||||||
| WBStrain00022564 | |||||||||
| WBStrain00022565 | |||||||||
| WBStrain00022676 | |||||||||
| WBStrain00026463 | |||||||||
| WBStrain00026855 | |||||||||
| WBStrain00026937 | |||||||||
| WBStrain00026938 | |||||||||
| WBStrain00026942 | |||||||||
| WBStrain00026943 | |||||||||
| WBStrain00026944 | |||||||||
| WBStrain00027028 | |||||||||
| WBStrain00027044 | |||||||||
| WBStrain00034371 | |||||||||
| WBStrain00040367 | |||||||||
| WBStrain00040622 | |||||||||
| WBStrain00040623 | |||||||||
| WBStrain00040624 | |||||||||
| Laboratory | CB | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00006752 | |||||||
| Interactor | WBInteraction000518152 | ||||||||
| WBInteraction000555944 | |||||||||
| Genetics | Mapping_data | In_2_point | 204 | ||||||
| 737 | |||||||||
| 2513 | |||||||||
| 6044 | |||||||||
| 6118 | |||||||||
| In_multi_point | 17 | ||||||||
| 33 | |||||||||
| 283 | |||||||||
| 308 | |||||||||
| 390 | |||||||||
| 399 | |||||||||
| 401 | |||||||||
| 638 | |||||||||
| 981 | |||||||||
| 984 | |||||||||
| 989 | |||||||||
| 993 | |||||||||
| 1221 | |||||||||
| 1231 | |||||||||
| 1374 | |||||||||
| 1693 | |||||||||
| 2283 | |||||||||
| 2284 | |||||||||
| 2288 | |||||||||
| 3006 | |||||||||
| 3007 | |||||||||
| 3009 | |||||||||
| 3012 | |||||||||
| 3158 | |||||||||
| 3159 | |||||||||
| In_pos_neg_data | 746 | ||||||||
| 755 | |||||||||
| 764 | |||||||||
| 7284 | |||||||||
| 8071 | |||||||||
| 8080 | |||||||||
| 8092 | |||||||||
| 8099 | |||||||||
| 8106 | |||||||||
| 8113 | |||||||||
| 8118 | |||||||||
| Description | Phenotype | WBPhenotype:0000054 | Paper_evidence | WBPaper00032269 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | Low | Paper_evidence | WBPaper00032269 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000153 | Paper_evidence | WBPaper00032190 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals exhibited increased contractions. | Paper_evidence | WBPaper00032190 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Genotype | zxIs6 | Paper_evidence | WBPaper00032190 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001316 | Paper_evidence | WBPaper00032190 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | ACh photo-ePSCs were drastically reduced, even during repeated stimulation. | Paper_evidence | WBPaper00032190 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Genotype | zxIs6 | Paper_evidence | WBPaper00032190 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000306 | Paper_evidence | WBPaper00032190 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Expression of ChR2-YFP in cholinergic neurons was not affected. | Paper_evidence | WBPaper00032190 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Genotype | zxIs6 | Paper_evidence | WBPaper00032190 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001278 | Paper_evidence | WBPaper00050142 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "In contrast, mutations that block small molecule neurosecretion, unc-13(e1091) or unc-18(e81), had no effect on the mitochondrial stress response to polyQ40 expression in the nervous system (Figure 4A)." | Paper_evidence | WBPaper00050142 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | GO_term | GO:0034514 | PATO:0000460 | Paper_evidence | WBPaper00050142 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Genotype | rmIs101 [rgef-1p::Q40::YFP]; zcIs13 [hsp-6p::GFP] | Paper_evidence | WBPaper00050142 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0001285 | Paper_evidence | WBPaper00045598 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Exposure of mutant strains to 10% CO2 showed pumping behavior similar to that of wild-type strains. | Paper_evidence | WBPaper00045598 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Affected_by | Molecule | WBMol:00003023 | Paper_evidence | WBPaper00045598 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001426 | Paper_evidence | WBPaper00004883 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Genotype | arIs37 | Paper_evidence | WBPaper00004883 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001800 | Paper_evidence | WBPaper00033094 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | Normal increase in pnlp-29::GFP expression after infection. | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0001838 | Paper_evidence | WBPaper00033094 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | The PMA-induced upregulation of pnlp-29::GFP expression was normal in mutant worms | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0001840 | Paper_evidence | WBPaper00033094 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | Normal increase in pnlp-29::GFP expression after wounding | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00033094 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Genotype | frIs7 [pnlp-29::GFP] | Paper_evidence | WBPaper00033094 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Reference | WBPaper00021052 | ||||||||
| WBPaper00032269 | |||||||||
| WBPaper00004883 | |||||||||
| WBPaper00016569 | |||||||||
| WBPaper00013927 | |||||||||
| WBPaper00033094 | |||||||||
| WBPaper00004535 | |||||||||
| WBPaper00032190 | |||||||||
| WBPaper00013649 | |||||||||
| WBPaper00016086 | |||||||||
| WBPaper00016275 | |||||||||
| WBPaper00013815 | |||||||||
| WBPaper00016396 | |||||||||
| WBPaper00016218 | |||||||||
| WBPaper00016074 | |||||||||
| WBPaper00023495 | |||||||||
| WBPaper00045598 | |||||||||
| WBPaper00050142 | |||||||||
| WBPaper00061175 | |||||||||
| WBPaper00064979 | |||||||||
| Remark | |||||||||
| Method | Allele |
