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WormBase Tree Display for Variation: WBVar00143592

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Name Class

WBVar00143592NamePublic_namee912
Other_nameF59G1.4a.1:c.250-263_947-68del
HGVSgCHROMOSOME_II:g.5896964_5902373del
Sequence_detailsSMapS_parentSequenceF59G1
Flanking_sequencesaggaaggaacaagtcgatcggaaaattttattttcacactgggagctagttccaataaaa
Mapping_targetF59G1
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004403
WBStrain00006311
WBStrain00026764
WBStrain00026863
WBStrain00027055
WBStrain00027229
WBStrain00027586
WBStrain00040213
WBStrain00040275
WBStrain00051497
LaboratoryCB
StatusLive
AffectsGeneWBGene00002993
WBGene00198855
WBGene00199631
WBGene00197123
WBGene00019128
TranscriptF59G1.6
F59G1.13VEP_consequencetranscript_ablation
VEP_impactHIGH
Exon_number1/1
F59G1.10VEP_consequencetranscript_ablation
VEP_impactHIGH
Exon_number1/1
F59G1.4a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScF59G1.4a.1:c.250-263_947-68del
Intron_number4-10/14
Exon_number5-10/15
F59G1.12VEP_consequencetranscript_ablation
VEP_impactHIGH
Exon_number1/1
Interactor (17)
IsolationMutagen
GeneticsInterpolated_map_positionII-0.855656
Mapping_dataIn_2_point40
777
4220
In_multi_point (11)
In_pos_neg_data3708
4223
4224
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
PenetranceHighSevere Egl phenotype is also observed at 15 CPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Range9999Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000022Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000033Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkHeterochronic defectPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0000065Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayGenotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000070Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayGenotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000113Paper_evidenceWBPaper00056201
Curator_confirmedWBPerson44293
RemarkFigure 2a, e912 mutants have elevated SL1-LCE expression at later larval stagesPaper_evidenceWBPaper00056201
Curator_confirmedWBPerson44293
WBPhenotype:0000114Paper_evidenceWBPaper00026761
Curator_confirmedWBPerson712
RemarkCompared to the greater than 5-fold decrease in lin-14 and in lin-28 mRNA levels in wild-type worms, the levels of these mRNAs remained nearly constant from the L1- to the L2-stage in lin-4(e912) worms.Paper_evidenceWBPaper00026761
Curator_confirmedWBPerson712
WBPhenotype:0000137Paper_evidenceWBPaper00031252
Curator_confirmedWBPerson712
RemarkIn mixed stage lin-4(lf) animals, the enrichment of lin-14 in the AIN-2 IP result is significantly decreased compared to that in the WT background. In contrast, the enrichment of two other known miRNA targets, hbl-1 and lin-28, was similarPaper_evidenceWBPaper00031252
Curator_confirmedWBPerson712
WBPhenotype:0000154Person_evidenceWBPerson13152
Curator_confirmedWBPerson712
WBPhenotype:0000164Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000201Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
RemarkAdult animals do not express adult-specific surface antigens.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005755PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAdult animals (n=300) were incubated with 6ul total anti-adult antiserum cross-adsorbed with N2 L4's and 14ul 125I-protein A.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
WBPhenotype:0000428Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkLacks adult cuticle.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000432Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAdult males lack copulatory structures.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000438Paper_evidenceWBPaper00001144
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkHeterochronic, retarded adult hermaphrodites. Easy to score (ES3) in adult, very hard to score (ES1) in larvae.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Animals continue past the L4 molt to an L5 stage animal, not to an adult stage.Paper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000643Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkabnormal movementPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000698Paper_evidenceWBPaper00000762
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
PenetranceCompleteAt 15 C, 4 percent of e912 hermaphrodites have recognizable vulval structuresPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Range100100Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive20Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0001228Paper_evidenceWBPaper00001144
Person_evidenceWBPerson13152
Curator_confirmedWBPerson712
RemarkAnimals do not form adult lateral alae.Paper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
WBPhenotype:0001414Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Remarkmale mating is completely abolishedPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
PenetranceHighPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayGenotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0001687Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
RemarkAdult animals do not express adult-specific surface antigens.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005755PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAdult animals (n=300) were incubated with 6ul total anti-adult antiserum cross-adsorbed with N2 L4's and 14ul 125I-protein A.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
WBPhenotype:0001923Person_evidenceWBPerson13152
Curator_confirmedWBPerson712
WBPhenotype:0002154Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
RemarkExtracts from late L2 stage wild-type and lin-4(e912) mutant animals showed that experimentally validated target mRNAs, lin-14 and lin-28, were shifted into the polysomal fraction in the mutant. By contrast, polysome association of the control mRNAs act-1 and ama-1 and the let-7 target daf-12 is identical in lin-4(e912) and wild-type animals.Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
WBPhenotype:0002157Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
Remarklin-14 and lin-28 transcript levels are increased in lin-4 mutants compared with wild-type animals, whereas daf-12, act-1 and ama-1 mRNA levels remain unchanged.Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
WBPhenotype:0004001Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkHermaphrodite mating never successful (HME0) at 20C, rarely successful (HME1) at 15C.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive20Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000207Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkDefecation cycle is normalPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0000634Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkPumping is normalPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0000637Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkNo defects in dauer formationPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0001233Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkCell number and nuclear staining is normalPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentDAPI stainingPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0002535Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Remarknon-DyfPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005666PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005667PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005668PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005665PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005661PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0007807PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0007808PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentDiO stainingPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Reference (35)
MethodDeletion_allele