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WormBase Tree Display for Variation: WBVar00092632

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Name Class

WBVar00092632NamePublic_nameok1417
Other_nameC14B1.4.1:c.292_940del
CE00901:p.Cys98AsnfsTer22
HGVSgCHROMOSOME_III:g.3705641_3706335del
Sequence_detailsSMapS_parentSequenceC14B1
Flanking_sequencesaaaatcgatttcttcagctaaattttccccaaatggatcatcagtggttccgaagattgta
Mapping_targetC14B1
Type_of_mutationDeletion
PCR_productOK1417_external
OK1417_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000041
WBStrain00032003
WBStrain00056267
LaboratoryRB
ZAS
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00006474
TranscriptC14B1.4.1 (11)
InteractorWBInteraction000519739
WBInteraction000519740
WBInteraction000521442
WBInteraction000521443
DescriptionPhenotypeWBPhenotype:0000030Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
RemarkAnimals did not show any obvious developmental defects at 15C however animals took longer to reach adulthood at 25C.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
WBPhenotype:0000050Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
RemarkThe wdr-5 mutant produces 45% embryonic lethality at 25 deg C.Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
WBPhenotype:0000061Paper_evidenceWBPaper00036383
WBPaper00058938
WBPaper00060474
Curator_confirmedWBPerson11446
WBPerson8962
WBPerson8633
RemarkFigure 1, homozygous mutant populations acquire longevity only after multiple generations post-thaw or after homozygosingPaper_evidenceWBPaper00058938
Curator_confirmedWBPerson8962
WBPhenotype:0000154Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
RemarkAverage brood size 44 at 20 deg C, 19 at 25 deg C.Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
WBPhenotype:0000275Paper_evidenceWBPaper00060474
Curator_confirmedWBPerson8633
RemarkFigure 1, larval arrest and lifespan shortening were observed upon UV treatment.Paper_evidenceWBPaper00060474
Curator_confirmedWBPerson8633
WBPhenotype:0000743Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
RemarkAnimals showed less severe RNAi-induced phenotypes than wild-type for five out of seven genes tested.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
Phenotype_assayTreatmentL4 animals were submitted to different RNAi feeding experiments at 20C.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
Temperature20Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
WBPhenotype:0000966Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
RemarkAnimals exhibited late onset sterility, occurring between generation F3 and F4. Animals also exhibited late-onset embryonic lethality, Him and additional somatic defects.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
Phenotype_assayTemperature20, 25Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
WBPhenotype:0001383Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
RemarkDi- and trimethylation levels were found to be significantly decreased.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
Phenotype_assayTreatmentGlobal levels of histone H3 K4 methylation were tested on total extracts prepared from synchronized adult populations by using antibodies directed against di- or trimethylated H3K4.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
WBPhenotype:0002078Paper_evidenceWBPaper00038409
WBPaper00036383
Curator_confirmedWBPerson712
WBPerson11446
RemarkAt the two-cell stage, H3K4me3 deposition was detected, though the signal appeared weaker than in wild type worms. At four-cell stage, the H3K4me3 mark was unable to be detected No defect in levels of deposition of H3K27me2 or of H3K27me3. At the eight-cell stage, as well as at post-gastrulation, the H3K4me3 mark is undetectable in wdr-5, mutants compared to N2. H3K4me3 is undetectable in Western blot analysis. | In wdr-5 gonads, the H3K4me3 mark is detectable, but its deposition pattern has changed compared to controls; the zone normally low in H3K4me3 levels is extended in wdr-5 mutants.Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
These worms have lower global levels of H3K4me3Paper_evidenceWBPaper00036383
Curator_confirmedWBPerson11446
WBPhenotype:0002167Paper_evidenceWBPaper00058938
Curator_confirmedWBPerson8962
RemarkFigure 3, determined by H3K9me2 ChIP-seqPaper_evidenceWBPaper00058938
Curator_confirmedWBPerson8962
ReferenceWBPaper00038409
WBPaper00036383
WBPaper00032309
WBPaper00058938
WBPaper00060474
WBPaper00065754
Remarkok1417 has a 695-bp deletion starting at position 354 and ending at position 1050 within the coding sequence.Person_evidenceWBPerson467
Sequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele