WormBase Tree Display for Variation: WBVar00092488

WBVar00092488 Name: Public_name: ok1240
    Other_name: ZC504.2.2:c.412-25_1151-21del
      ZC504.2.1:c.412-25_1151-21del
    HGVSg: CHROMOSOME_X:g.10414558_10415766del
  Sequence_details: SMap: S_parent: Sequence: ZC504
    Flanking_sequences: gtaataaaaaaatgtcttgatatttttaat tgattaattctctctctcagatatcgggcc
    Mapping_target: ZC504
    Type_of_mutation: Deletion
    PCR_product: OK1240_external
      OK1240_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00031896
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00000047
    Transcript: ZC504.2.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: ZC504.2.1:c.412-25_1151-21del
        Intron_number: 5-11/13
        Exon_number: 6-11/14
      ZC504.2.2 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: ZC504.2.2:c.412-25_1151-21del
        Intron_number: 5-11/13
        Exon_number: 6-11/14
    Interactor: WBInteraction000518504
  Isolation: Mutagen: UV/TMP
  Genetics: Mapping_data: In_multi_point: 4886
  Description: Phenotype: WBPhenotype:0001203 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: Mutants of acr-8(ok1240) showed a significant resistance to nicotine in paralysis assays Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000421 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: Mutants of acr-8(ok1240) showed no levamisole resistance Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00034730
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00041959
        Curator_confirmed: WBPerson557
      WBPhenotype:0000681 Paper_evidence: WBPaper00027611
        Curator_confirmed: WBPerson712
        Remark: Scored as DMPP sensitive. Paper_evidence: WBPaper00027611
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00000896 Paper_evidence: WBPaper00027611
              Curator_confirmed: WBPerson712
      WBPhenotype:0000886 Paper_evidence: WBPaper00035548
        Curator_confirmed: WBPerson712
        Remark: Animals are superficially wild-type. Paper_evidence: WBPaper00035548
            Curator_confirmed: WBPerson712
      WBPhenotype:0001316 Paper_evidence: WBPaper00034730
        Curator_confirmed: WBPerson2021
        Remark: PSCs for ACh, levamisole, or nicotine did not differ between wild type and acr-8(ok1240) Paper_evidence: WBPaper00034730
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001468 Paper_evidence: WBPaper00041959
        Curator_confirmed: WBPerson557
        Remark: Mutant worms exhibited a normal approach to a benzaldehyde stimulus. Paper_evidence: WBPaper00041959
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Worms placed on chemotaxis plates spotted with 0.01% benzaldehyde. Paper_evidence: WBPaper00041959
              Curator_confirmed: WBPerson557
  Reference: WBPaper00041959
    WBPaper00027611
    WBPaper00035548
    WBPaper00034730
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele