WormBase Tree Display for Variation: WBVar00091540

WBVar00091540 Name: Public_name: ok237
    HGVSg: CHROMOSOME_X:g.4710347_4712575del
  Sequence_details: SMap: S_parent: Sequence: CHROMOSOME_X
    Flanking_sequences: ttttgagaaggcggtggaggcatggcaatc ttcgctaaaaaattgagccaatttattatt
    Mapping_target: CHROMOSOME_X
    Type_of_mutation: Deletion
    PCR_product: ok237_external
      ok237_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00033400
      WBStrain00037702
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00018878
      WBGene00200170
      WBGene00001032
      WBGene00199202
    Transcript: K02G10.8b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: ?-615
        CDS_position: ?-611
        Protein_position: ?-204
        Intron_number: 2/4
        Exon_number: 1-3/5
      DL2.2 VEP_consequence: transcript_ablation
        VEP_impact: HIGH
        Exon_number: 1/1
      F55D10.3.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2/5
        Exon_number: 1-2/6
      K02G10.8a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: ?-621
        CDS_position: ?-611
        Protein_position: ?-204
        Intron_number: 2/4
        Exon_number: 1-3/5
      DL2.1 VEP_consequence: transcript_ablation
        VEP_impact: HIGH
        Exon_number: 1/1
  Isolation: Mutagen: UV/TMP
  Genetics: Mapping_data: In_multi_point: 4264
  Description: Phenotype: WBPhenotype:0000273 Paper_evidence: WBPaper00045410
        Curator_confirmed: WBPerson8908
        Remark: Very small, but significant, reduction in thrashing assays Paper_evidence: WBPaper00045410
            Curator_confirmed: WBPerson8908
      WBPhenotype:0001171 Paper_evidence: WBPaper00045410
          WBPaper00048929
        Curator_confirmed: WBPerson8908
        Remark: reduced lifespan Paper_evidence: WBPaper00045410
            Curator_confirmed: WBPerson8908
          reduced lifespan rescued by a drug (ethosuximide) Paper_evidence: WBPaper00048929
            Curator_confirmed: WBPerson8908
        Affected_by: Molecule: WBMol:00003963 Paper_evidence: WBPaper00048929
              Curator_confirmed: WBPerson8908
      WBPhenotype:0001398 Paper_evidence: WBPaper00045410
        Curator_confirmed: WBPerson8908
        Remark: Age-dependent loss of neurites and variations in the structure of neurites and cell bodies of unidentified sensory neurons in the head Paper_evidence: WBPaper00045410
            Curator_confirmed: WBPerson8908
      WBPhenotype:0001434 Paper_evidence: WBPaper00045410
          WBPaper00048929
        Curator_confirmed: WBPerson8908
        Remark: Age-dependent reduction in chemotaxis toward chemoattractants and food sources Paper_evidence: WBPaper00045410
            Curator_confirmed: WBPerson8908
          reduced chemotaxis rescued by a drug (ethosuximide) Paper_evidence: WBPaper00048929
            Curator_confirmed: WBPerson8908
        Affected_by: Molecule: WBMol:00003963 Paper_evidence: WBPaper00048929
              Curator_confirmed: WBPerson8908
      WBPhenotype:0001620 Paper_evidence: WBPaper00053621
        Curator_confirmed: WBPerson28450
        Recessive: Paper_evidence: WBPaper00053621
          Curator_confirmed: WBPerson28450
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00053621
            Curator_confirmed: WBPerson28450
      WBPhenotype:0001621 Paper_evidence: WBPaper00053621
        Curator_confirmed: WBPerson28450
        Recessive: Paper_evidence: WBPaper00053621
          Curator_confirmed: WBPerson28450
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00053621
            Curator_confirmed: WBPerson28450
  Disease_info: Models_disease: DOID:14330
      DOID:14503
    Models_disease_in_annotation: WBDOannot00000331
      WBDOannot00000637
  Reference: WBPaper00045410
    WBPaper00048929
    WBPaper00053621
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele