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WormBase Tree Display for Variation: WBVar00090656

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Name Class

WBVar00090656EvidencePaper_evidenceWBPaper00002543
NamePublic_namen3091
Other_nameY71F9B.5a.2:c.163C>T
CE28810:p.Gln55Ter
CE25569:p.Gln55Ter
Y71F9B.5b.1:c.163C>T
Y71F9B.5a.1:c.163C>T
HGVSgCHROMOSOME_I:g.2708198C>T
Sequence_detailsSMapS_parentSequenceY71F9B
Flanking_sequencestatttcccgaataccattctacacaacgataacacacggtaagcccccttcaccaataat
Mapping_targetY71F9B
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00002543
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00008495
WBStrain00027350
LaboratoryMT
StatusLive
AffectsGeneWBGene00003006
TranscriptY71F9B.5a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScY71F9B.5a.1:c.163C>T
HGVSpCE25569:p.Gln55Ter
cDNA_position193
CDS_position163
Protein_position55
Exon_number3/11
Codon_changeCaa/Taa
Amino_acid_changeQ/*
Y71F9B.5b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScY71F9B.5b.1:c.163C>T
HGVSpCE28810:p.Gln55Ter
cDNA_position194
CDS_position163
Protein_position55
Exon_number3/11
Codon_changeCaa/Taa
Amino_acid_changeQ/*
Y71F9B.5a.2VEP_consequencestop_gained
VEP_impactHIGH
HGVScY71F9B.5a.2:c.163C>T
HGVSpCE25569:p.Gln55Ter
cDNA_position490
CDS_position163
Protein_position55
Exon_number4/12
Codon_changeCaa/Taa
Amino_acid_changeQ/*
InteractorWBInteraction000500222
WBInteraction000500223
WBInteraction000502406
WBInteraction000502798
WBInteraction000521878
WBInteraction000538657
WBInteraction000538660
WBInteraction000538734
WBInteraction000538737
GeneticsInterpolated_map_positionI-7.43257
DescriptionPhenotypeWBPhenotype:0000104Paper_evidenceWBPaper00003570
WBPaper00004579
Curator_confirmedWBPerson712
WBPerson557
RemarkLess than 10% of animals exhibit normal asymmetric T cell division polarity. The majority of mutants exhibit symmetric divisions while the remained exhibit reversed polarity.Paper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
In lin-17 animals, which display a loss of T cell polarity, the level of POP-1 was high in both T cell daughters (it is higher in the anterior T cell daughter in wild-type animals).Paper_evidenceWBPaper00004579
Curator_confirmedWBPerson557
PenetranceHighPaper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0004946PATO:0000460Paper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
WBbt:0004944PATO:0000460Paper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
WBbt:0008409PATO:0000460Paper_evidenceWBPaper00004579
Curator_confirmedWBPerson557
WBPhenotype:0000111Paper_evidenceWBPaper00004579
Curator_confirmedWBPerson557
RemarkIn lin-17 animals, which display a loss of T cell polarity, the level of POP-1 was high in both T cell daughters (it is higher in the anterior T cell daughter in wild-type animals).Paper_evidenceWBPaper00004579
Curator_confirmedWBPerson557
EQ_annotationsAnatomy_termWBbt:0008409PATO:0000460Paper_evidenceWBPaper00004579
Curator_confirmedWBPerson557
WBPhenotype:0000155Paper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
Remark10% of animals exhibit T cell divisions with reversed polarity.Paper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
PenetranceHighPaper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0004946PATO:0000460Paper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
WBbt:0004944PATO:0000460Paper_evidenceWBPaper00003570
Curator_confirmedWBPerson712
WBPhenotype:0000257Paper_evidenceWBPaper00002543
Curator_confirmedWBPerson712
RemarkAdult hermaphrodites exhibited phasmid defects as assayed by DiO dye-filling.Paper_evidenceWBPaper00002543
Curator_confirmedWBPerson712
WBPhenotype:0000414Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
RemarkThe lin-17(n3091) mutation resulted in a transformation of V5.pa fate in V6-ablated animals from seam cells to the postdeirid neuroblast in 33% of animals (Table 2)Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
The lin-17(n3091) mutation resulted in a transformation of V5.pa fate in V2,V3,V4-ablated animals from seam cells to the postdeirid neuroblast in 9% of animals (Table 4)Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
PenetranceIncomplete33% penetrancePaper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
Low9% penetrancePaper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007447PATO:0000460Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
WBbt:0007464PATO:0000460Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
WBPhenotype:0000469Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
PenetranceIncomplete21Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004993PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0004086PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "Because QL descendants sometimes were misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. A QL cell descendant was scored as misplaced anteriorly if its nucleus was anterior to V4.p and misplaced posteriorly if its nucleus was posterior to V5.p. Because they occupy positions near each other, the data for SDQL and PVM were combined."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000828Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
RemarkTable 3Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
PenetranceIncomplete78Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004946PATO:0000460Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
WBbt:0004944PATO:0000460Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
WBPhenotype:0000961Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
Remark"We first confirmed that the expression of RNT-1::GFP has resumed in the T.ap cells in most (90%) of the 60 wild-type animals examined (Fig. 6C). In both lin-17 and lin-44 mutants, the expression pattern of RNT-1::GFP was indistinguishable from that of wild-type until the middle L1 stage. rnt-1 appeared to be unresponsive to the Wnt signaling up to this stage. Subsequently, however, lin-17 and lin-44 mutants began to show irregular expressions of RNT-1::GFP among the granddaughter cells. In the analysis of the lin-17 mutation, we examined 50 animals in which the T cell underwent symmetrical cell division giving rise to four hypodermal descendants (Figs. 6A, C). Only 14 animals (28%) showed a normal pattern of RNT-1::GFP expression (detectable in T.ap alone), whereas the great majority (72% in total) exhibited either aberrant expression in various cell combinations such as T.ap and T.pa or T.aa and T.pa, etc. (38%), or no expression at all in any of the four granddaughters (34%)."Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004946PATO:0000460Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
WBbt:0004944PATO:0000460Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
Phenotype_assayGenotypeRNT-1::GFPPaper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
WBPhenotype:0001375Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
Remarklin-17(n3091) resulted in a complete loss of mab-5::GFP expression from the muIs16 transgene in V5.pa and V5.pp cells following ablation of V6 cells (Table 2)Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
PenetranceCompletePaper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007447PATO:0000460Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
WBbt:0007464PATO:0000460Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
WBbt:0007452PATO:0000460Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
WBbt:0007469PATO:0000460Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
Phenotype_assayGenotypemuIs16 [mab-5::GFP]Paper_evidenceWBPaper00003428
Curator_confirmedWBPerson2987
WBPhenotype:0001585Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
RemarkTable 3Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
PenetranceIncomplete78Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004946PATO:0000460Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
WBbt:0004944PATO:0000460Paper_evidenceWBPaper00026860
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000232Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006827PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "A CAN was scored as defective if its nucleus was anterior to the V3 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000469Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004991PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0003832PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "Because they occupy positions near each other, the data for SDQR and AVM were combined and are presented in the QR column. SDQR and AVM were scored as defective if their nuclei were posterior to the V2.a nucleus. The position of AQR, a third QR descendant, was not included because it migrates to a location near other nuclei with similar morphology."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000470Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "Because the HSNs were sometimes misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. An HSN was scored as misplaced anteriorly if its nucleus was anterior to the P5/6 nucleus and as misplaced posteriorly if its nucleus was posterior to the V4 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000471Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom the Table 1 legend: "An ALM was scored as defective if its nucleus was anterior to the V2 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000594Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006826PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "Because BDUs sometimes were misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. A BDU was scored as misplaced anteriorly if its nucleus was anterior to its normal position immediately anterior to V1 and misplaced posteriorly if its nucleus was posterior to the V1 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0001660Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
RemarkNo disruption of ASE asymmetry (as seen with lim-6 reporters)Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Phenotype_assayGenotypeotIs114, otIs6Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
ReferenceWBPaper00004579
WBPaper00024898
WBPaper00003428
WBPaper00006052
WBPaper00003570
WBPaper00026860
WBPaper00002543
MethodSubstitution_allele