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WormBase Tree Display for Variation: WBVar00090245

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Name Class

WBVar00090245EvidencePaper_evidenceWBPaper00025674
NamePublic_namen1761
Other_nameC37F5.1b.1:c.1017+1G>A
C37F5.1a.1:c.1137+1G>A
HGVSgCHROMOSOME_IV:g.2277191C>T
Sequence_detailsSMapS_parentSequenceC37F5
Flanking_sequencesggtaggactcccggtcttggcgagagtcagttggtttttttctaaatacgaaatatttat
Mapping_targetC37F5
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00003160
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00027309
LaboratoryMT
StatusLive
AffectsGeneWBGene00002990
TranscriptC37F5.1a.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScC37F5.1a.1:c.1137+1G>A
Intron_number5/6
C37F5.1b.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScC37F5.1b.1:c.1017+1G>A
Intron_number4/5
InteractorWBInteraction000524405
GeneticsInterpolated_map_positionIV-8.49247
DescriptionPhenotypeWBPhenotype:0000216Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
Remarkdefect in Bγ cell fate specificationPaper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
EQ_annotationsAnatomy_termWBbt:0007830PATO:0000460Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
GO_termGO:0001708PATO:0000460Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
Phenotype_assayControl_strainWBStrain00044748Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
Treatmentceh-13::gfp as marker of Bγ cell fate syIs145 PS4807 contains the ceh-13::GFP integrated transgene syIs145 that was obtained by microinjection of pMF1 at 10 ng/μl, pBS at 20 ng/μl and unc-119(+) at 40 ng/μl into unc-119(ed4); him-5(e1490) mutant animals.Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
GenotypesIys145 [ceh-13::GFP]Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
WBPhenotype:0000239Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
Remarklin-1(n1761gf) mutant animals generated fewer P5.p - P7.p descendant nuclei than wild type animals (Table 2)Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
PenetranceIncomplete54% penetrantPaper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0008590PATO:0000460Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
Phenotype_assayGenotypedpy-20(e1282)Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
WBPhenotype:0001278Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
Remarkdecreased sIys145 expression in BγPaper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
EQ_annotationsAnatomy_termWBbt:0007830PATO:0000460Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
GO_termGO:0010467PATO:0000460Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
Phenotype_assayControl_strainWBStrain00044748Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
Treatmentceh-13::gfp as marker of Bγ cell fate syIs145 PS4807 contains the ceh-13::GFP integrated transgene syIs145 that was obtained by microinjection of pMF1 at 10 ng/μl, pBS at 20 ng/μl and unc-119(+) at 40 ng/μl into unc-119(ed4); him-5(e1490) mutant animals.Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
GenotypesIys145 [ceh-13::GFP]Paper_evidenceWBPaper00035553
Curator_confirmedWBPerson625
ReferenceWBPaper00035553
WBPaper00005255
WBPaper00025674
MethodSubstitution_allele