WormBase Tree Display for Variation: WBVar00089874

WBVar00089874 Name: Public_name: n998
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00001208
    Interactor: WBInteraction000003393
      WBInteraction000541253
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Penetrance: Complete: Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Range: 100 100 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000031 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
      WBPhenotype:0000111 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Ectopic expression of mec-7. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000154 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Remark: Mutants show a 36 percent drop in brood size (compared to wild-type) Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000180 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: axon defects Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000224 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: HSN cell bodies do not contain serotonin Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
      WBPhenotype:0000339 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: moderate bloating Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES2_Difficult_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000414 Paper_evidence: WBPaper00040420
        Curator_confirmed: WBPerson712
        Remark: Mutation alters FLP neuron fate to a TRN-like fate. Although expression of the mec-3-dependent FLP marker sto-5p::gfp remains unaffected in egl-44 mutant animals. Paper_evidence: WBPaper00040420
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006828 PATO:0000460 Paper_evidence: WBPaper00040420
                Curator_confirmed: WBPerson712
      WBPhenotype:0000425 Paper_evidence: WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: Serotonin levels are reduced in HSNs (determined immunocytochemically). (Data not shown) Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000470 Paper_evidence: WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: HSNs fail to arrive at their final destination (between P5/6 and V4). Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000038 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000843 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Remark: males mate poorly (mating efficiency is 42 percent) Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001224 Paper_evidence: WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: Data not shown Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001340 Paper_evidence: WBPaper00001133
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: See Table 1 Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
          not stimulated by imipramine Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: High: Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Range: 90 90 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 0.75 mg/ml imipramine Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Temperature: 24 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0001068 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 7.5 mg/ml serotonin Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Temperature: 24 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001629 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: stimulated by serotonin Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
  Reference: WBPaper00040420
    WBPaper00016216
    WBPaper00001105
    WBPaper00001133
  Method: Allele