WormBase Tree Display for Interaction: WBInteraction000541253
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| WBInteraction000541253 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001210 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr878 | ||||
| Construct | WBCnstr00013518 | ||||
| WBGene00001208 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00089874 | Interactor_type | Trans_regulator | ||
| Interaction_summary | FLP expression of gfp::egl-46 was very weak or undetect- able in animals with the egl-44(n998) loss-of-function mutation; the expression in other neurons, such as AVM, PVM, and HSN cells was similar to that seen in wild-type animals. In addition, the level of egl-46 mRNA in egl-44(n998) mutants was four- to fivefold lower than in wild type (data not shown). (Even though GFP::EGL-46 is expressed in several cells, the GFP fluorescence expression is most intense and lasts longest in the FLP cells. The reduction in mRNA, thus, probably reflects the loss of FLP expression.) These observations indicate that egl-44 is needed for sufficient and persistent egl-46 expression in FLP cells. | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [egl-46::gfp] | ||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Does_not_regulate | Anatomy_term | WBbt:0003832 | ||
| WBbt:0006830 | |||||
| WBbt:0004086 | |||||
| Paper | WBPaper00004624 |
