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WormBase Tree Display for Variation: WBVar00089663

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Name Class

WBVar00089663EvidencePaper_evidenceWBPaper00001306
NamePublic_namen676
Other_nameR107.8.1:c.2651G>A
CE00274:p.Gly884Asp
HGVSgCHROMOSOME_III:g.9062738C>T
Sequence_detailsSMapS_parentSequenceR107
Flanking_sequencesggcttgcaaagaagggaatcgattcttttgtattccaatctcagaagctcttgtcgcaga
Mapping_targetR107
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00001306
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00007981
WBStrain00007982
WBStrain00008018
WBStrain00008019
WBStrain00008020
WBStrain00008021
LaboratoryMT
StatusLive
Linked_toWBVar02141279
WBVar00089665
WBVar00089664
AffectsGeneWBGene00003001
TranscriptR107.8.1 (12)
InteractorWBInteraction000052177
WBInteraction000052475
IsolationMutagenEMS
GeneticsInterpolated_map_positionIII0.132774
Mapping_dataIn_multi_point890
891
892
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
RemarkEgg-laying defect is a direct consequence of the trasnformation of the presumptive AC into a VU.Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
PenetranceIncompleteFor heterozygote; penetrance for heterozygote is higher at 20 deg.Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Range7070Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Semi_dominantPaper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Phenotype_assayTreatmentVisual inspection at 25 degrees.Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Temperature25Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Genotypen676/+Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
WBPhenotype:0000170Paper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
RemarkAdult lateral alae were present in 30% L4 (n=40) and 100% adult (n=33) animals.Paper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007832PATO:0000460Paper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
Life_stageWBls:0000038PATO:0000460Paper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
Phenotype_assayTemperature15CPaper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
WBPhenotype:0000414Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
RemarkBoth Z1.ppp and Z1.aaa adopt a VU fate; in WT one of these cells becomes an anchor cell (adopts the AC fate) and signal from the AC signals the other cell to adopt a VU fate.Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
PenetranceCompletePaper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Phenotype_assayTreatmentAblation of all other somatic gonadal cells to isolate Z1.ppp or Z4.aaa.Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
WBPhenotype:0000640Paper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
Phenotype_assayTemperature15CPaper_evidenceWBPaper00031590
Curator_confirmedWBPerson712
WBPhenotype:0000698Paper_evidenceWBPaper00028987
WBPaper00000762
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
Remarksemidominant Vul phenotypePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceComplete75 percent penetrance under heterozygous conditions, 100 percent penetrance under homozygous conditionsPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Semi_dominantPaper_evidenceWBPaper00000762
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
EQ_annotationsAnatomy_termWBbt:0006748PATO:0000460Paper_evidenceWBPaper00028987
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00028987
Curator_confirmedWBPerson2021
WBls:0000057PATO:0000460Paper_evidenceWBPaper00000762
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
Phenotype_assayGenotypedpy-17(e164)Paper_evidenceWBPaper00028987
Curator_confirmedWBPerson2021
WBPhenotype:0000700Paper_evidenceWBPaper00001306
WBPaper00028987
WBPaper00032182
Curator_confirmedWBPerson48
WBPerson2021
WBPerson712
RemarkCharacteristic of transformation of the vulval precursor cell fates.Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
A low percentage of animals exhibited psuedovulvae.Paper_evidenceWBPaper00032182
Curator_confirmedWBPerson712
PenetranceLowRare in homozygotes, heterozygotes, and hemizygotes.Paper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Paper_evidenceWBPaper00028987
WBPaper00032182
Curator_confirmedWBPerson2021
WBPerson712
Range2121Paper_evidenceWBPaper00028987
Curator_confirmedWBPerson2021
Semi_dominantPaper_evidenceWBPaper00001306
Curator_confirmedWBPerson48
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00032182
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006748PATO:0000460Paper_evidenceWBPaper00028987
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00028987
Curator_confirmedWBPerson2021
Phenotype_assayGenotypedpy-17(e164)Paper_evidenceWBPaper00028987
Curator_confirmedWBPerson2021
Reference (14)
MethodSubstitution_allele