WormBase Tree Display for Variation: WBVar00089534

WBVar00089534 Name: Public_name: n487
    Other_name: n1084 Paper_evidence: WBPaper00003631
      n1796 Paper_evidence: WBPaper00003631
  Sequence_details: SMap: S_parent: Sequence: VF23B12L
    Flanking_sequences: TATTGGGTATTGTTTACTCCTAACCGGGTG TCCATAAAATTCTATTGTCCCAGATTTAGG
    Mapping_target: VF23B12L
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00003631
            Person_evidence: WBPerson117
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026625
      WBStrain00026787
      WBStrain00026979
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00001170
    Interactor: WBInteraction000518991
  Genetics: Interpolated_map_position: V 6.30574
    Mapping_data: In_2_point: 721
      In_multi_point: 605
        606
        615
        748
        942
        1179
        1180
  Description: Phenotype (31)
    Phenotype_not_observed: WBPhenotype:0000386 Paper_evidence: WBPaper00035318
        Curator_confirmed: WBPerson2987
        Remark: Cobalt-induced germline cell apoptosis was unaffected in egl-1(n487) mutants (Figure 2) Paper_evidence: WBPaper00035318
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00003058 Paper_evidence: WBPaper00035318
              Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Synchronized young adult hermaphrodites were treated in K-medium with 0.01 millimolar Cobalt chloride for 12 hours, and apoptotic cells were scored after AO staining. Paper_evidence: WBPaper00035318
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001024 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: No phenotype in male. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0001068 Paper_evidence: WBPaper00000635
          WBPaper00001133
        Curator_confirmed: WBPerson48
          WBPerson2021
        Dominant: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 5 mg/ml serotonin Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
            7.5 mg/ml serotonin Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Temperature: 24 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001336 Paper_evidence: WBPaper00000635
        Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: As described in Hodgkin, Horvitz, and Brenner (1979), six L4 males and six L4 dpy-11 hermaphrodites incubated for 24 hours, males removed, and hermaphrodites transferred to fresh dishes each day. Cross-progeny are counted. Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
      WBPhenotype:0001629 Paper_evidence: WBPaper00031977
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Animals were insensitive to the egg-laying inducing effects of 5HT (serotonin) (n=50). Paper_evidence: WBPaper00031977
            Curator_confirmed: WBPerson712
          Stimulated by serotonin. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Dominant: Paper_evidence: WBPaper00031977
          Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00031977
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
  Reference (17)
  Method: Substitution_allele