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WormBase Tree Display for Variation: WBVar00088387

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Name Class

WBVar00088387EvidencePaper_evidenceWBPaper00002930
NamePublic_nameky10
Other_nameB0212.5.1:c.517C>T
CE20445:p.Gln173Ter
HGVSgCHROMOSOME_IV:g.3556045G>A
Sequence_detailsSMapS_parentSequenceB0212
Flanking_sequencesGCGGCCTGAAACATTGTGTTATCTTTAGGCAATCAGCCCTCCACCTAGCCATTGTACACG
Mapping_targetB0212
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00002930
Person_evidenceWBPerson40923
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005214
WBStrain00007483
WBStrain00052609
LaboratoryCX
StatusLive
AffectsGeneWBGene00003889
TranscriptB0212.5.1VEP_consequencestop_gained,splice_region_variant
VEP_impactHIGH
HGVScB0212.5.1:c.517C>T
HGVSpCE20445:p.Gln173Ter
cDNA_position517
CDS_position517
Protein_position173
Exon_number5/15
Codon_changeCaa/Taa
Amino_acid_changeQ/*
Interactor (17)
GeneticsInterpolated_map_positionIV-3.15548
DescriptionPhenotype (34)
Phenotype_not_observedWBPhenotype:0000302Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Phenotype_assayTreatment1:200 dilution of benzaldehydePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBPhenotype:0000304Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Phenotype_assayTreatment1:100 dilution of isoamyl alcoholPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBPhenotype:0000306Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RemarkAWA specific expression of odr-7::GFP is unaltered in osm-9 mutantsPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Phenotype_assayGenotypekyIs38Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBPhenotype:0000398Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RemarkMutants respond to stroking to the body with a hairPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBPhenotype:0000481Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
Remarkosm-9 mutants (osm-9: solvent vs Argentine ant extract, t(40) = 1.434, p = 0.239). Within groups exposed to Argentine ant compounds, the response of osm-9 mutants was significantly different from both PD1074 (t(40) = 2.990, p = 0.010) and tax-4 mutants (t(40) = 3.189, p = 0.006).Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
Extracts of the Velvety tree ant showed a different pattern of behavioral response, in which tax-4 mutants were repelled by the extracts (tax-4: solvent vs Velvety tree ant extract, t(40) = 5.645, p < 0.001), but osm-9 mutants (osm-9: solvent vs Velvety tree ant extract, t(40) = 0.018, p = 0.985) and the wild type (PD1074: solvent vs Velvety tree ant extract, t(40) = 1.096, p = 0.373) were not.Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00008002Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
WBMol:00008001Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
WBPhenotype:0000630Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003904Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005665PATO:0000460Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBPhenotype:0000905Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RemarkThe morphology of AWA and ASH neurons is normalPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBbt:0005665PATO:0000460Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBPhenotype:0001084Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
Phenotype_assayTreatmentChemotaxis assay for a 10 minute timepoint.Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
WBPhenotype:0001085Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Phenotype_assayTreatment1:1000 dilution of butanonePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBPhenotype:0001086Paper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
Phenotype_assayTreatment1:1000 dilution of trimethylthiazolePaper_evidenceWBPaper00002930
Curator_confirmedWBPerson2021
WBPhenotype:0001435Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
Phenotype_assayTreatmentChemotaxis assay for a 10 minute timepoint.Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
WBPhenotype:0001442Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
Phenotype_assayTreatmentChemotaxis assay for a 10 minute timepoint.Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
WBPhenotype:0001454Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
RemarkIndividual loss of neither OSM-9 nor OCR-2 function affected response to 10mM quinine (Figure 1A), similar to our previous report (Ezak et al. 2010). Further, osm-9 and ocr-2 single mutants responded similarly to wild-type animals across the range of quinine concentrations tested (10mM - 1mM, Figure 1A).Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003904Paper_evidenceWBPaper00059946
Curator_confirmedWBPerson712
WBPhenotype:0001469Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
RemarkAnimals exhibited attraction to butanone similar to wild-type animals.Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005086Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005665PATO:0000460Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
WBbt:0005661PATO:0000460Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
WBPhenotype:0001484Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
Phenotype_assayTreatmentChemotaxis assay for a 10 minute timepoint.Paper_evidenceWBPaper00005150
Curator_confirmedWBPerson48
WBPhenotype:0001741Paper_evidenceWBPaper00032000
Curator_confirmedWBPerson712
Remark<10% males displayed spontaneous spicule-muscle seizures in the presence or absence of food.Paper_evidenceWBPaper00032000
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005826PATO:0000460Paper_evidenceWBPaper00032000
Curator_confirmedWBPerson712
WBbt:0005312PATO:0000460Paper_evidenceWBPaper00032000
Curator_confirmedWBPerson712
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00032000
Curator_confirmedWBPerson712
Phenotype_assayTreatmentTo effect food deprivation animals were moved to plates with no food (E. coli) or fed inedible bacteria (aztreonam-treated E. coli).Paper_evidenceWBPaper00032000
Curator_confirmedWBPerson712
WBPhenotype:0001765Paper_evidenceWBPaper00031935
WBPaper00031936
Curator_confirmedWBPerson712
WBPerson2021
RemarkCarbon dioxide avoidance (Cdad) was not defective in the presence or absence of food.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
Mutants respond normally to CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentStrains were maintained at 22C. Animals were exposed to a 5% to 0% CO2 gradient.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
WBPhenotype:0001780Paper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
RemarkMutants show normal butanone enhancementPaper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentPreexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assaysPaper_evidenceWBPaper00029060
Curator_confirmedWBPerson2021
WBPhenotype:0001939Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003731Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00003904Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00003565Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00001530Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
WBMol:00005022Paper_evidenceWBPaper00035961
Curator_confirmedWBPerson712
Reference (25)
RemarkManually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00003889 Ochre_UAA Q(173) to stopPaper_evidenceWBPaper00002930
MethodSubstitution_allele