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WormBase Tree Display for Variation: WBVar00088058

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Name Class

WBVar00088058EvidencePaper_evidenceWBPaper00032244
NamePublic_namejc36
Other_nameY57G11C.24j.1:c.465+243_589+1053del
Y57G11C.24d.1:c.414+243_538+1053del
Y57G11C.24n.1:c.633+243_757+1053del
Y57G11C.24i.1:c.630+243_754+1053del
Y57G11C.24o.1:c.633+243_757+1053del
Y57G11C.24g.1:c.630+243_754+1053del
Y57G11C.24h.1:c.630+243_754+1053del
Y57G11C.24a.1:c.465+243_589+1053del
Y57G11C.24k.1:c.414+243_538+1053del
HGVSgCHROMOSOME_IV:g.14888849_14890386del
Sequence_detailsSMapS_parentSequenceY57G11C
Flanking_sequencestgtttcaatatgttattatctaaacattaaaaagtgaaacggtcacagaagtttgaaaaa
Mapping_targetY57G11C
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005395
LaboratorySU
StatusLive
AffectsGeneWBGene00050271
WBGene00171425
WBGene00167744
WBGene00165917
WBGene00174402
WBGene00169931
WBGene00014594
WBGene00001330
WBGene00047720
WBGene00167979
Transcript (18)
InteractorWBInteraction000503805
GeneticsInterpolated_map_positionIV12.5952
DescriptionPhenotypeWBPhenotype:0000050Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkAnimals displayed 100% embryonic lethality. Most embryos did not hatch.Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBPhenotype:0000366Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkEmbryos showed normal muscle twitching and vigorous movement within the eggshell; however these movements stopped after elongation arrest.Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBPhenotype:0000436Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkFunctional VAB-19::GFP was correctly localized to longitudinal bands in embryos prior to their elongation arrest; however, in later embryos, after arrest, the localization became disorganized and never clearly localized to circumferential stripes.Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005733PATO:0000460Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
Phenotype_assayGenotypejuIs169 (VAB-19::GFP)Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBPhenotype:0000474Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkAnimals showed defects in muscle attachment.Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBPhenotype:0001354Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkActin distribution became disorganized by the two-fold stage. After the two-fold stage, intermediate filaments expanded into regions of epidermal cells that were not adjacent to muscle, as observed by MH4 immunostaining. Actin filaments were more randomly oriented or missing from the apical surface of the epidermis. Actin filaments were also disorganized and fragmented in lateral epidermal cells, as observed by phalloidin staining. By the three-fold stage, Myotactin remained in longitudinal bands rather than circumferential stripes as it resided in wild-type animals, as observed by MH46 immunostaining.Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005733PATO:0000460Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBbt:0005753PATO:0000460Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
Life_stageWBls:0000020PATO:0000460Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBPhenotype:0001478Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkEmbryos elongated at a normal rate to the 2.5 to 3-fold stage then stopped elongating ~1hr after the two-fold stage (n=12).Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBPhenotype:0001521Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkEmbryos elongated at a normal rate to the 2.5 to 3-fold stage, stopped elongating ~1hr after the two-fold stage then partly retracted (n=12).Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
WBPhenotype:0001735Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
RemarkEmbryos showed normal muscle twitching and vigorous movement within the eggshell; however these movements stopped after elongation arrest.Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000021PATO:0000460Paper_evidenceWBPaper00032244
Curator_confirmedWBPerson712
ReferenceWBPaper00032244
MethodDeletion_allele