WormBase Tree Display for Variation: WBVar00054417

WBVar00054417 Name: Public_name: ct46
    Other_name: T01G9.5a.1:c.296C>T
      CE06342:p.Pro99Leu
      CE32479:p.Pro99Leu
      T01G9.5b.1:c.296C>T
    HGVSg: CHROMOSOME_I:g.8295227C>T
  Sequence_details: SMap: S_parent: Sequence: T01G9
    Flanking_sequences: aaagtggaagtccagagccacctgcagacc agatgtttggtccaaaccatcgccaccgtt
    Mapping_target: T01G9
    Type_of_mutation: Substitution: c t Person_evidence: WBPerson399
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00008444
      WBStrain00026463
    Laboratory: BW
    Status: Live
  Linked_to: WBVar00054422
    WBVar00054427
    WBVar02125078
  Affects: Gene: WBGene00003183
    Transcript: T01G9.5a.1 (12)
      T01G9.5b.1 (12)
    Interactor: WBInteraction000051975
      WBInteraction000051979
      WBInteraction000051980
      WBInteraction000051982
      WBInteraction000519223
      WBInteraction000519224
      WBInteraction000556055
      WBInteraction000556056
      WBInteraction000578852
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: I 2.70613
    Mapping_data: In_multi_point: 1764
        1765
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00032438
        Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00032438
              Curator_confirmed: WBPerson712
      WBPhenotype:0000351 Paper_evidence: WBPaper00032438
        Curator_confirmed: WBPerson712
        Remark: Hatching rate reduced at all temperatures, defect slightly better at 15 deg C (13% hatching). Paper_evidence: WBPaper00032438
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00032438
              Curator_confirmed: WBPerson712
      WBPhenotype:0000436 Paper_evidence: WBPaper00004129
        Curator_confirmed: WBPerson557
        Remark: Mislocalization of MEI-2 to mitotic chromatin and centrosomes in mei-1(ct46gf) mutant embryos. Paper_evidence: WBPaper00004129
            Curator_confirmed: WBPerson557
        Dominant: Paper_evidence: WBPaper00004129
          Curator_confirmed: WBPerson557
        Variation_effect: Gain_of_function_undetermined_type: Paper_evidence: WBPaper00004129
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Mutant embryos were fixed and stained with anti-MEI-2 antibodies. Paper_evidence: WBPaper00004129
              Curator_confirmed: WBPerson557
      WBPhenotype:0001175 Paper_evidence: WBPaper00033119
        Curator_confirmed: WBPerson2021
        Remark: 1.4% Him among the surviving mei-1 progeny Paper_evidence: WBPaper00033119
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00033119
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: tbb-2(sb26) in background Paper_evidence: WBPaper00033119
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001343 Paper_evidence: WBPaper00033119
        Curator_confirmed: WBPerson2021
        Remark: Meiotic metaphase spindles were significantly shorter than wild type Paper_evidence: WBPaper00033119
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00033119
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00033119
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Time-lapse imaging of GFP-tubulin in mei-1(ct46) embryos Paper_evidence: WBPaper00033119
              Curator_confirmed: WBPerson2021
          Genotype: tbb-2(sb26) in background Paper_evidence: WBPaper00033119
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001743 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: normal meiosis followed by abnormal mitoses Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
  Reference (12)
  Method: Substitution_allele