WormBase Tree Display for Variation: WBVar00000109

WBVar00000109 Evidence: Paper_evidence: WBPaper00004836
  Name: Public_name: ak4
    Other_name: CE30128:p.Glu352_Ter750delextTer?
      F07F6.6.1:c.1054_2250del
    HGVSg: CHROMOSOME_II:g.5443296_5445175del
  Sequence_details: SMap: S_parent: Sequence: F07F6
    Flanking_sequences: tttaatgataaatgtgaacgaattggagtc atatgggattcaactcgactggaatttgaa
    Mapping_target: F07F6
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (13)
    Laboratory: VM
    Status: Live
  Affects: Gene: WBGene00003774
    Transcript: F07F6.6.1 (11)
    Interactor: WBInteraction000501705
  Genetics: Interpolated_map_position: II -1.51326
    Mapping_data: In_multi_point: 4538
  Description: Phenotype (11)
    Phenotype_not_observed: WBPhenotype:0000006 Paper_evidence: WBPaper00032082
        Curator_confirmed: WBPerson712
        Remark: All these animals retained a similar number of eggs when compared to wild-type animals (~10 eggs). Paper_evidence: WBPaper00032082
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Young well-fed animals were scored Paper_evidence: WBPaper00032082
              Curator_confirmed: WBPerson712
          Temperature: 25 Paper_evidence: WBPaper00032082
              Curator_confirmed: WBPerson712
      WBPhenotype:0000019 Paper_evidence: WBPaper00032082
        Curator_confirmed: WBPerson712
        Remark: Animals did not exhibit reduced pharyngeal pumping when compared with daf-7(e1375). Paper_evidence: WBPaper00032082
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Pumping rates were assayed for well-fed , pheromone-untreated; food-deprived, pheromone-untreated; and well-fed, pheromone-treated animals. Pheromone treatment consisted of transfer of animals grown under well-fed conditions to plates containing 30 ul/ml of a dauer-pheromone prep (Golden and Riddle, 1982) and 30 ml of OP50 E. coli food. Paper_evidence: WBPaper00032082
              Curator_confirmed: WBPerson712
          Temperature: 20 Paper_evidence: WBPaper00032082
              Curator_confirmed: WBPerson712
      WBPhenotype:0000062 Paper_evidence: WBPaper00031974
        Curator_confirmed: WBPerson712
      WBPhenotype:0000147 Paper_evidence: WBPaper00031974
        Curator_confirmed: WBPerson712
        Remark: Starved animals showed an enhanced slowing in response to food (data not shown). Paper_evidence: WBPaper00031974
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00031974
        Curator_confirmed: WBPerson712
        Remark: Animals showed no gross locomotion defect (data not shown). Paper_evidence: WBPaper00031974
            Curator_confirmed: WBPerson712
      WBPhenotype:0001072 Paper_evidence: WBPaper00031974
        Curator_confirmed: WBPerson712
        Remark: Animals moved more slowly in response to food (data not shown). Paper_evidence: WBPaper00031974
            Curator_confirmed: WBPerson712
      WBPhenotype:0001084 Paper_evidence: WBPaper00031974
        Curator_confirmed: WBPerson712
        Remark: Animals showed normal chemotaxis to NaCl in mock-conditioned assays and avoided NaCl just after conditioning. Paper_evidence: WBPaper00031974
            Curator_confirmed: WBPerson712
      WBPhenotype:0001462 Paper_evidence: WBPaper00032335
        Curator_confirmed: WBPerson712
        Remark: Animals did not show defects in chemotaxis to NaCl compared to wild type. Paper_evidence: WBPaper00032335
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00032335
              Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were tested for response to 25 mM NaCl. Paper_evidence: WBPaper00032335
              Curator_confirmed: WBPerson712
      WBPhenotype:0001765 Paper_evidence: WBPaper00031936
        Curator_confirmed: WBPerson2021
        Remark: Mutants defective in the synthesis and reception of nonessential excitatory neurotransmitters respond normally to CO2 Paper_evidence: WBPaper00031936
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001817 Paper_evidence: WBPaper00032335
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited enhanced-gustatory plasticity, i.e. strong avoidance to NaCl after starvation, similar to that observed for wild type. Paper_evidence: WBPaper00032335
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00032335
              Curator_confirmed: WBPerson712
      WBPhenotype:0002370 Paper_evidence: WBPaper00059155
        Curator_confirmed: WBPerson10038
        Remark: Quote from paper: "The results illustrated in Figure 3 suggest that mutants associated with glutamate receptor glr-1, glr-2, nmr-1, nmr-2 thermal avoidance was not affected." Paper_evidence: WBPaper00059155
            Curator_confirmed: WBPerson10038
        Phenotype_assay: Strain: WBStrain00040168 Paper_evidence: WBPaper00059155
              Curator_confirmed: WBPerson10038
          Control_strain: WBStrain00000001 Paper_evidence: WBPaper00059155
              Curator_confirmed: WBPerson10038
  Disease_info: Models_disease: DOID:1289
    Models_disease_in_annotation: WBDOannot00000907
      WBDOannot00000908
  Reference (16)
  Method: Deletion_allele