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WormBase Tree Display for Variation: WBVar00000056

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Name Class

WBVar00000056NamePublic_namead702
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005505
LaboratoryDA
StatusLive
AffectsGeneWBGene00001145
InteractorWBInteraction000052107
WBInteraction000518037
WBInteraction000524571
WBInteraction000524573
WBInteraction000571242
GeneticsMapping_dataIn_multi_point2469
2470
DescriptionPhenotypeWBPhenotype:0000016Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkMeasured by the fraction of animals moving after incubation on 0.1mM aldicarb agar pads. ~0.09 animals were moving compared to ~0.79 N2 animals.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007833PATO:0001549Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0000060Paper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
RemarkDead adults have a transparent, shrunken appearancePaper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0007833PATO:0001422Paper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
WBPhenotype:0000334Paper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
RemarkBacteria in the corpus and isthmus are not efficiently moved posteriorly during pharyngeal pumpingPaper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0003734PATO:0000460Paper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
WBbt:0003733PATO:0000460Paper_evidenceWBPaper00001709
Curator_confirmedWBPerson2021
WBPhenotype:0001506Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Remarkeat-16(ad702) mutants exhibited an increased spontaneous reversal rate, compared to wild type animals (Figure 5)Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBPhenotype:0001618Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an EC50 of ~1.10 for halothane, whereas N2 has an EC50 of ~0.42 vol%, as determined by a concentration-response curve based on animal dispersal indexes.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001705Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0001619Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an EC50 of ~1.33 for isoflurane, whereas N2 has an EC50 of ~0.75 vol% as determined by a concentration-response curve based on animal dispersal indexes.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004563Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0001918Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Remarkeat-16(ad702) mutants exhibited a hypersensitive avoidance response to 0.25 molar glycerol, compared to wild type controls (Figure 2b)Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003633Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBPhenotype:0002056Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkstrong EatPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsGO_termGO:0042755PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0002077Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
Remarkeat-16(ad702) mutants resistant to the paralytic effects of exogenous dopamine.Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
WBPhenotype:0002114Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
Phenotype_not_observedWBPhenotype:0000481Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Remarkeat-16(ad702) mutants exhibited a wild type avoidance response to high osmotic strength (1 molar glycerol) compared to wild type controls (Figure 2a).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
eat-16(ad702) mutants exhibited a wild type avoidance response to 10 millimolar quinine compared to wild type controls (Figure 2a).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003633Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBMol:00003904Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBPhenotype:0000641Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit a similar Dispersal Index (DI) as N2.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Phenotype_assayTreatmentDispersal assay as reported in Crowder et al.1996; van Swinderen et al. 1997. Dipersal measured in air.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0002114Paper_evidenceWBPaper00038270
Curator_confirmedWBPerson712
RemarkAnimals do not become paralyzed after 10 minutes of swimming.Paper_evidenceWBPaper00038270
Curator_confirmedWBPerson712
WBPhenotype:0002199Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
RemarkThe eat-16(ad702) mutation did not affect the calcium transients in ASH neurons in response to high osmolarity (1M glycerol) (Figure 4a)Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
ReferenceWBPaper00038270
WBPaper00001709
WBPaper00004721
WBPaper00004281
WBPaper00037778
WBPaper00010578
WBPaper00041132
WBPaper00065340
MethodAllele