WormBase Tree Display for Variation: WBVar00000056
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WBVar00000056 | Name | Public_name | ad702 | ||||||
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Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00005505 | ||||||||
Laboratory | DA | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00001145 | |||||||
Interactor | WBInteraction000052107 | ||||||||
WBInteraction000518037 | |||||||||
WBInteraction000524571 | |||||||||
WBInteraction000524573 | |||||||||
WBInteraction000571242 | |||||||||
Genetics | Mapping_data | In_multi_point | 2469 | ||||||
2470 | |||||||||
Description | Phenotype | WBPhenotype:0000016 | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Measured by the fraction of animals moving after incubation on 0.1mM aldicarb agar pads. ~0.09 animals were moving compared to ~0.79 N2 animals. | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003650 | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0007833 | PATO:0001549 | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000060 | Paper_evidence | WBPaper00001709 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Dead adults have a transparent, shrunken appearance | Paper_evidence | WBPaper00001709 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0007833 | PATO:0001422 | Paper_evidence | WBPaper00001709 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Life_stage | WBls:0000041 | PATO:0000460 | Paper_evidence | WBPaper00001709 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000334 | Paper_evidence | WBPaper00001709 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Bacteria in the corpus and isthmus are not efficiently moved posteriorly during pharyngeal pumping | Paper_evidence | WBPaper00001709 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0003734 | PATO:0000460 | Paper_evidence | WBPaper00001709 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
WBbt:0003733 | PATO:0000460 | Paper_evidence | WBPaper00001709 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001506 | Paper_evidence | WBPaper00037778 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | eat-16(ad702) mutants exhibited an increased spontaneous reversal rate, compared to wild type animals (Figure 5) | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001618 | Paper_evidence | WBPaper00004721 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals exhibit an EC50 of ~1.10 for halothane, whereas N2 has an EC50 of ~0.42 vol%, as determined by a concentration-response curve based on animal dispersal indexes. | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00001705 | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001619 | Paper_evidence | WBPaper00004721 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals exhibit an EC50 of ~1.33 for isoflurane, whereas N2 has an EC50 of ~0.75 vol% as determined by a concentration-response curve based on animal dispersal indexes. | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00004563 | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001918 | Paper_evidence | WBPaper00037778 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | eat-16(ad702) mutants exhibited a hypersensitive avoidance response to 0.25 molar glycerol, compared to wild type controls (Figure 2b) | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Affected_by | Molecule | WBMol:00003633 | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0002056 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | strong Eat | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | GO_term | GO:0042755 | PATO:0000460 | Person_evidence | WBPerson261 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002077 | Paper_evidence | WBPaper00041132 | |||||||
Curator_confirmed | WBPerson557 | ||||||||
Remark | eat-16(ad702) mutants resistant to the paralytic effects of exogenous dopamine. | Paper_evidence | WBPaper00041132 | ||||||
Curator_confirmed | WBPerson557 | ||||||||
WBPhenotype:0002114 | Paper_evidence | WBPaper00041132 | |||||||
Curator_confirmed | WBPerson557 | ||||||||
Phenotype_not_observed | WBPhenotype:0000481 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | eat-16(ad702) mutants exhibited a wild type avoidance response to high osmotic strength (1 molar glycerol) compared to wild type controls (Figure 2a). | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
eat-16(ad702) mutants exhibited a wild type avoidance response to 10 millimolar quinine compared to wild type controls (Figure 2a). | Paper_evidence | WBPaper00037778 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Affected_by | Molecule | WBMol:00003633 | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBMol:00003904 | Paper_evidence | WBPaper00037778 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000641 | Paper_evidence | WBPaper00004721 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals exhibit a similar Dispersal Index (DI) as N2. | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Dispersal assay as reported in Crowder et al.1996; van Swinderen et al. 1997. Dipersal measured in air. | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002114 | Paper_evidence | WBPaper00038270 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals do not become paralyzed after 10 minutes of swimming. | Paper_evidence | WBPaper00038270 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002199 | Paper_evidence | WBPaper00037778 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | The eat-16(ad702) mutation did not affect the calcium transients in ASH neurons in response to high osmolarity (1M glycerol) (Figure 4a) | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Reference | WBPaper00038270 | ||||||||
WBPaper00001709 | |||||||||
WBPaper00004721 | |||||||||
WBPaper00004281 | |||||||||
WBPaper00037778 | |||||||||
WBPaper00010578 | |||||||||
WBPaper00041132 | |||||||||
WBPaper00065340 | |||||||||
Method | Allele |