WormBase Tree Display for Transgene: WBTransgene00001725

WBTransgene00001725 Public_name: pkIs1642
  Summary: [unc-119(+) + R11A8.5(+) + sir-2.1(+)]
  Synonym: [sir-2.1(+) + unc-119(+)]
    [sir-2.1(O/E)]
    [unc-119(+) + R11A8.5(+) + sir-2.1(+); unc-119(+)]
    [unc-119(+) PO R11A8.5(+) sir-2.1(+)]
    [unc-119(+); sir-2.1(+) R11A8.5(+)]
  Construction: Construct: WBCnstr00001714
    Coinjection_other: unc-119(+)
    Integration_method: Particle_bombardment
  Construction_summary: The transgene in pkIs1642 includes the sir-2.1 coding sequence plus 2.5 kb of upstream sequence, including the predicted gene R11A8.5, subcloned into a pRP2510 vector. pkIs1642 was generated by bombardment of unc-119(ed3) bearing worms with the full operon construct along with pRP2510, containing a copy of wild type unc-119.
  Genetic_information: Integrated
    Phenotype_not_observed: WBPhenotype:0000061 Paper_evidence: WBPaper00040229
        Curator_confirmed: WBPerson712
        Remark: Strain NL3909 (pkIs1642 [sir-2.1 unc-119] unc-119(ed3)) exhibits increased lifespan relative to the control strain NL3908 (pkIs1641 [unc-119] unc-119(ed3)); however, outcrossing (x6) of NL3909 abrogated longevity. Paper_evidence: WBPaper00040229
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00004800 Paper_evidence: WBPaper00040229
            Curator_confirmed: WBPerson712
  Associated_with: Strain: WBStrain00007685
      WBStrain00029023
  Reference: WBPaper00026929
    WBPaper00027682
    WBPaper00037688
    WBPaper00040184
    WBPaper00040229
    WBPaper00042148
    WBPaper00044152
    WBPaper00048525
    WBPaper00055782
    WBPaper00058832
  Species: Caenorhabditis elegans