WormBase Tree Display for RNAi: WBRNAi00088416
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| WBRNAi00088416 | Homol | Homol_homol | F10G7:RNAi | ||
|---|---|---|---|---|---|
| Sequence_info | DNA_text | ATGTTCTATGCACAGTTCGTTCTCGCCAAAAAGGGACCGTTGGCAAAAGTGTGGCTGGCAGCTCACTGGGAAAAAAAGCTGACAAAGGCGCAAATCTTCGAAACAGATGTTCCCCAAGCGATCGAGGAAGTCATTCGCCCCAAGGTTAAAATGGCGCTCCGAACAGTTGGACATCTTCTCCTTGGAATCGTGAGAATCTACTCGAAGAAGACACGATATCTTCTGGCTGATACAAATGAAGCGTATCAAAAGATGAAGATTAACTTCCGCAACGGATTCAGTTTTGAAGTCGACATTCCAGAGAATGCAGAAATTGAAGAGGATTTCTCAAACTTCATTGATAAGTACAATATCACAGTGCCCGAGTTCCACGATGCCGACTACAATGAGCAGCTCATTATGGCTAATGTGAGCCGTCGTGAAGACATCACCATGAAAGAAACCGTCAATTTCAATGTCGAGTTCAACATTGACGCAGATTTCGATGGGTTCGGTGACGAAGGAGAATCTTGGCAACTCGATCATCTCTACGGATCGGTGGAACCTTTGTCTTTGCGCCCCACTCCTCAGCCAGAATCGTTGATGGAAGTCGAACGAGATCGTGATGTGGCTGCAAATGGAACGGAAATTTCCCGTATAGATGCGGATAGTGTGATTTTCTCCGAAGGACCAACACGTCCAAATCTTATTTTTGACAATCAGGAAGGCGGAAATTTCATGCCTGAAATGAACCTGAAGGTTGAGAATCAAACACTGGAAAACGATGGTGGTGTTGGGCCTGCTGATATGTTCAGCTCAATGATTCATCCCGTCAGAGAGCATGCTGTCGCAGATGTTCAAAACGACGATGGTATGGACTTTGACTATCAACCGTTCGAGCCTGAAAACGTTGAGCCATCGAGACCACAAAGTCCCGAGTCATTTGCCCTGGAGCCTCTAGATGTGGAGCACATGGAAGGACGGAAAAAACGTCAGAGAAAAGCGAGAAAGCTGATTGTCGATGCTGAAACTATGATTTCAAACGACGCTTTCCGAGAGCAACAAGAAGACTTCTCCGATACGATGCGAGTAGTTGAAATGGCGCCTCCTACCAGAAAGATGTTCAATTTATGCGTCAGCGGAGATCTTCAACACCTCAGCCGTGAACCTGGATGCAAAATGTTCAACAGAGAACTCCTTCAAAGATACAGGAGATGTTTGGTCACCCGAGAGTTCGATCTCAATTACACCATGCAAGAGTTGAGCGATAGTTCGAGTTTCACTCCGTCAATGGAAGCTCAAGCTGAGCCATGGGAGGACTTGAACCTCAATGAGGACATTCAAGAAGATATTCAAGCGCAGGGACCAGCCGTTGATGAATTCTTTAATGATGTGCGCATGGATGATGATGATGACAGACAACCAGCTCAGGAAATGGACTTTGGTGACAACTTCGATTTTCCACAAGAAGTAGAACATCAAGAGTGTGCTCCGATCCCTATCCAGAGTGGATTCGCTGGAGAGAACAAAGAGAACGAGGACGCAGAGGATTGGTCTGATCCGTTCGGTTCTTCAAATTCCAGCAGACGTGGCCAGCTTGAAGCCTATGGATTCGGAAATACTTCGACCTACAAGGAAGACGATGGCAAATGGGCGAAACGCGCCAAGCACATTCTAAAGAAAGTCTCCGCGGATATTGAGACTTCGGGACAAGCGGACTTCTCATCTGTCACAGCAACTGCCAAGAATCGCAAGCAAGCTGCAGAGCAATTTTATTCGTTGCTTACCCTGGCCAAGTCTCAAGCAATAAGTGTTGATCAATCAGAGCCATACGGAGAGATCGTAATTCGTCCAGGAGCCAATTTCAAAGAAGCATGTCCACTGAGCTCTCCGAAACCGATGGGACTTGGAAATACAATGGAAAATTCCACTATGAGAACCCCAATGAGACCAGTTTAA | |||
| Experiment | Laboratory | YM | |||
| Date | 01 Jun 2003 00:00:00 | ||||
| Strain | WBStrain00000001 | ||||
| Temperature | 20 | ||||
| Delivered_by | Soaking | ||||
| Inhibits | Predicted_gene | F10G7.4 | Inferred_automatically | RNAi_primary | |
| Gene | WBGene00004737 | Inferred_automatically | RNAi_primary | ||
| Transcript | F10G7.4.1 | Inferred_automatically | RNAi_primary | ||
| Species | Caenorhabditis elegans | ||||
| Reference | WBPaper00005937 | ||||
| Phenotype | WBPhenotype:0000050 | Remark | F1 embryos exhibited embryonic lethality with complete penetrance. Authors carefully observed the cell division process in scc-1/coh-2(RNAi) embryos, and found similar chromosome segregation defects in early cell cycles to the scc-3(RNAi), him-1/smc-1(RNAi), or smc-3(RNAi) embryos, although the penetrance was relatively low. This low penetrance (~10% of the RNAi-affected embryos) might be due to either gene-specific inefficiency of RNAi reaction or relatively high stability of the SCC-1/COH-2 protein compared with other cohesin components. The scc-1/coh-2(RNAi) embryos showed loose metaphase plates, asynchronous separation of chromosomes at anaphase, and formation of multiple nuclei after decondensation of chromosomes. | ||
| Penetrance | Complete | ||||
| WBPhenotype:0000059 | Remark | F1 embryos exhibited embryonic lethality with complete penetrance. Authors carefully observed the cell division process in scc-1/coh-2(RNAi) embryos, and found similar chromosome segregation defects in early cell cycles to the scc-3(RNAi), him-1/smc-1(RNAi), or smc-3(RNAi) embryos, although the penetrance was relatively low. This low penetrance (~10% of the RNAi-affected embryos) might be due to either gene-specific inefficiency of RNAi reaction or relatively high stability of the SCC-1/COH-2 protein compared with other cohesin components. The scc-1/coh-2(RNAi) embryos showed loose metaphase plates, asynchronous separation of chromosomes at anaphase, and formation of multiple nuclei after decondensation of chromosomes. | |||
| WBPhenotype:0000688 | Remark | F1 embryos exhibited embryonic lethality with complete penetrance. Authors carefully observed the cell division process in scc-1/coh-2(RNAi) embryos, and found similar chromosome segregation defects in early cell cycles to the scc-3(RNAi), him-1/smc-1(RNAi), or smc-3(RNAi) embryos, although the penetrance was relatively low. This low penetrance (~10% of the RNAi-affected embryos) might be due to either gene-specific inefficiency of RNAi reaction or relatively high stability of the SCC-1/COH-2 protein compared with other cohesin components. The scc-1/coh-2(RNAi) embryos showed loose metaphase plates, asynchronous separation of chromosomes at anaphase, and formation of multiple nuclei after decondensation of chromosomes. | |||
| WBPhenotype:0000697 | Remark | F1 embryos exhibited embryonic lethality with complete penetrance. Authors carefully observed the cell division process in scc-1/coh-2(RNAi) embryos, and found similar chromosome segregation defects in early cell cycles to the scc-3(RNAi), him-1/smc-1(RNAi), or smc-3(RNAi) embryos, although the penetrance was relatively low. This low penetrance (~10% of the RNAi-affected embryos) might be due to either gene-specific inefficiency of RNAi reaction or relatively high stability of the SCC-1/COH-2 protein compared with other cohesin components. The scc-1/coh-2(RNAi) embryos showed loose metaphase plates, asynchronous separation of chromosomes at anaphase, and formation of multiple nuclei after decondensation of chromosomes. | |||
| WBPhenotype:0000773 | Remark | F1 embryos exhibited embryonic lethality with complete penetrance. Authors carefully observed the cell division process in scc-1/coh-2(RNAi) embryos, and found similar chromosome segregation defects in early cell cycles to the scc-3(RNAi), him-1/smc-1(RNAi), or smc-3(RNAi) embryos, although the penetrance was relatively low. This low penetrance (~10% of the RNAi-affected embryos) might be due to either gene-specific inefficiency of RNAi reaction or relatively high stability of the SCC-1/COH-2 protein compared with other cohesin components. The scc-1/coh-2(RNAi) embryos showed loose metaphase plates, asynchronous separation of chromosomes at anaphase, and formation of multiple nuclei after decondensation of chromosomes. | |||
| Penetrance | Complete | ||||
| Remark | paper remark: Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation. Authors used yk256h5(scc-1/coh-2). | ||||
| Method | RNAi |
