WormBase Tree Display for Interaction: WBInteraction000578887
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| WBInteraction000578887 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00013732 | Interactor_type | Effector | |
| WBGene00020633 | Interactor_type | Effector | |||
| WBGene00021527 | Interactor_type | Effector | |||
| WBGene00000898 | Interactor_type | Affected | |||
| Variation_interactor | WBVar02157237 | Interactor_type | Effector | ||
| WBVar02157238 | Interactor_type | Effector | |||
| WBVar02157239 | Interactor_type | Effector | |||
| WBVar00088709 | Interactor_type | Affected | |||
| Interaction_summary | "To test the impact of AMP-binding on daf-2 longevity we generated daf-2; aakg-1; aakg-2; aakg-3 and daf-2; aakg-4; aakg-5 mutants and measured their lifespan compared to daf-2 mutation alone. Removing either family of aakg isoforms significantly suppressed daf-2 longevity (Figure 1F, p<0.001 for both comparisons), but similarly to the situation in WT animals, the effect was most pronounced when aakg-1, aakg-2, and aakg-3 were mutated." Incomplete suppression | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0000061 | ||||
| WBProcess | WBbiopr:00000001 | ||||
| Paper | WBPaper00062543 |
