WormBase Tree Display for Interaction: WBInteraction000563581

WBInteraction000563581 Interaction_type: Genetic: Unilateral_suppression
    GI_module_one: Mono_phenotypic
    GI_module_two: Suppressing
  Interactor: Interactor_overlapping_gene: WBGene00001031 Interactor_type: Effector
      WBGene00006760 Interactor_type: Affected
    Variation_interactor: WBVar00092623 Interactor_type: Affected
  Interaction_summary: From paper: "No obvious phenotype was observed upon knockdown of either dnj-12, dnj-13, or dnj-19 by feeding RNAi to wild-type nematodes (data not shown). Although RNAi against dnj-12 or dnj-19 also did not alter the life span of unc-23(ok1408) nematodes, RNAi against dnj-13 improved the health of the mutated strain. The life span of unc-23(ok1408) nematodes in the presence of RNAi against dnj-13 increased from roughly 5 days, as observed in untreated unc-23 deletion strains, to about 11 days (Fig. 7A). The debilitating growth phenotype was almost absent, with only a weak head-bent phenotype remaining (Fig. 7B). The motility as observed in thrashing assays also improved significantly (Fig. 7C). Further, the head muscle cells observable from the dense body structure in differential interference contrast images are apparent in RNAi-treated nematodes, whereas they are not visible in unc-23 mutated nematodes (Fig. 7D) (16). Thus, large parts of the phenotypes observed in unc-23 mutated nematodes originate only in the presence of DNJ-13, and the reduction of DNJ-13 levels by RNA interference restores the wild-type appearance."
  Throughput: Low_throughput
  Interaction_RNAi: WBRNAi00113783
  Interaction_phenotype: WBPhenotype:0001294
  Paper: WBPaper00045536