WormBase Tree Display for Gene: WBGene00006760
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| WBGene00006760 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_V | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-23 | Person_evidence | WBPerson261 | |||||
| Sequence_name | H14N18.1 | ||||||||
| Molecular_name | H14N18.1a | ||||||||
| H14N18.1a.1 | |||||||||
| CE17973 | |||||||||
| H14N18.1b | |||||||||
| CE33124 | |||||||||
| H14N18.1c | |||||||||
| CE37777 | |||||||||
| H14N18.1b.1 | |||||||||
| H14N18.1c.1 | |||||||||
| Other_name | vab-4 | ||||||||
| bag-2 | Paper_evidence | WBPaper00048629 | |||||||
| CELE_H14N18.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-23 | ||||||||
| DB_info | Database | AceView | gene | 5J419 | |||||
| WormQTL | gene | WBGene00006760 | |||||||
| WormFlux | gene | WBGene00006760 | |||||||
| NDB | locus_tag | CELE_H14N18.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006760|UniProtKB=O61980 | |||||||
| family | PTHR12334 | ||||||||
| NCBI | gene | 179272 | |||||||
| RefSeq | protein | NM_072906.7 | |||||||
| NM_182342.6 | |||||||||
| NM_001392570.1 | |||||||||
| TREEFAM | TREEFAM_ID | TF102012 | |||||||
| TrEMBL | UniProtAcc | Q5TKA9 | |||||||
| Q86S24 | |||||||||
| O61980 | |||||||||
| UniProt_GCRP | UniProtAcc | O61980 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 03 Nov 2015 10:56:26 | WBPerson2970 | Name_change | Other_name | bag-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142919 | ||||||||
| Allele (62) | |||||||||
| Legacy_information | e25 : `benthead' progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally hence very poor forward movement good reverse movement. Egl. ES3 (adult) ME1. NA8 (e324 : resembles e25; e611 (pka vab-4 : incompletely penetrant allele) etc.). | ||||||||
| See also e25, e462, e478, e611, e621, e988, e1182, e2154 | |||||||||
| [C.elegansII] e25 : "benthead" phenotype, progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally, hence very poor forward movement, good reverse movement; defects in muscle attachment (Mua); Egl. Phenotype partly suppressed by growth in liquid. ES3 (adult) ME1. OA>10: e324 (resembles e25), e611 (pka vab-4, impenetrant allele), e988, e2154 etc. [Waterston et al. 1980; CB; DR; NJ] | |||||||||
| Strain | WBStrain00032000 | ||||||||
| WBStrain00033526 | |||||||||
| WBStrain00034712 | |||||||||
| WBStrain00003976 | |||||||||
| WBStrain00003958 | |||||||||
| WBStrain00004081 | |||||||||
| WBStrain00004149 | |||||||||
| WBStrain00004186 | |||||||||
| WBStrain00005873 | |||||||||
| WBStrain00005890 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | unc-23 encodes a protein with similarity to the BAG2 (BCL2 AnthaGene) protein that functions to negatively regulate proteosomal degradation by the E3 ubiquitin ligase and Hsp70 co-chaperone CHIP (Carboxyl-terminus of Hsp70 Interacting Protein); in C. elegans, unc-23 is required for proper attachment of the anterior body wall musculature to the overlying hypodermis. | Paper_evidence | WBPaper00040313 | |||||
| WBPaper00000461 | |||||||||
| WBPaper00003943 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 29 Oct 2015 00:00:00 | ||||||||
| Automated_description | Enables ATPase activator activity and heat shock protein binding activity. Acts upstream of with a positive effect on muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Expressed in several structures, including anal depressor muscle; excretory canal; pharynx; touch receptor neurons; and vulva. Is an ortholog of human BAG2 (BAG cochaperone 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | H14N18.1a | |||||||
| H14N18.1b | |||||||||
| H14N18.1c | |||||||||
| Corresponding_transcript | H14N18.1a.1 | ||||||||
| H14N18.1b.1 | |||||||||
| H14N18.1c.1 | |||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf647031 | ||||||||
| WBsf647032 | |||||||||
| WBsf661014 | |||||||||
| WBsf661015 | |||||||||
| WBsf661510 | |||||||||
| WBsf981973 | |||||||||
| WBsf232176 | |||||||||
| WBsf232177 | |||||||||
| WBsf232178 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr11891 | ||||||||
| Expr12480 | |||||||||
| Expr1012508 | |||||||||
| Expr1032833 | |||||||||
| Expr1153142 | |||||||||
| Expr2017856 | |||||||||
| Expr2035992 | |||||||||
| Drives_construct | WBCnstr00019716 | ||||||||
| WBCnstr00019717 | |||||||||
| WBCnstr00034167 | |||||||||
| Construct_product | WBCnstr00021438 | ||||||||
| WBCnstr00034167 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (192) | |||||||||
| Interaction (27) | |||||||||
| Map_info | Map | V | Position | 1.8633 | Error | 0.014042 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mDf1 | |||||||
| sDf29 | |||||||||
| Positive_clone | H14N18 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | nDf42 | |||||||
| Mapping_data | 2_point | 129 | |||||||
| 840 | |||||||||
| 841 | |||||||||
| Multi_point (26) | |||||||||
| Pos_neg_data (12) | |||||||||
| Reference (57) | |||||||||
| Remark | Sequence connection from [Rahmani P, Moerman DG] | ||||||||
| Method | Gene |
