WormBase Tree Display for Interaction: WBInteraction000557937
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WBInteraction000557937 | Interaction_type | Regulatory | Change_of_localization | ||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00000140 | Interactor_type | Trans_regulated | |
Antibody | WBAntibody00000559 | ||||
WBGene00006816 | Interactor_type | Trans_regulator | |||
Variation_interactor | WBVar00089487 | Interactor_type | Trans_regulator | ||
Interaction_summary | "We tested whether ANC-1 localized properly in a collection of unc-84 mutant backgrounds. ANC-1 failed to localize to the nuclear periphery in the null unc-84 allele and in alleles that have missense mutations in or near the conserved SUN (for Sad1p, UNC-84 homology) domain of UNC-84 and that disrupt both nuclear migration and anchorage (6) (Fig. 2E). In contrast, ANC-1 was detected at the nuclear envelope in unc-84 alleles that have missense mutations or small deletions in the NH2-terminus of UNC-84 and that disrupt only migration (6) (Fig. 2F). ANC-1 was still detected at normal levels in the cytoplasm in all unc-84 mutants." | ||||
Detection_method | Antibody | ||||
Regulation_level | Post_translational | ||||
Regulation_result | Does_not_regulate | Life_stage | WBls:0000041 | ||
Subcellular_localization | cytoplasm | ||||
Paper | WBPaper00005468 | ||||
Remark | Fig. 2e |