WormBase Tree Display for Interaction: WBInteraction000557935
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| WBInteraction000557935 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00000140 | Interactor_type | Trans_regulated | |
| Antibody | WBAntibody00000559 | ||||
| WBGene00006816 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00089487 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "We tested whether ANC-1 localized properly in a collection of unc-84 mutant backgrounds. ANC-1 failed to localize to the nuclear periphery in the null unc-84 allele and in alleles that have missense mutations in or near the conserved SUN (for Sad1p, UNC-84 homology) domain of UNC-84 and that disrupt both nuclear migration and anchorage (6) (Fig. 2E). In contrast, ANC-1 was detected at the nuclear envelope in unc-84 alleles that have missense mutations or small deletions in the NH2-terminus of UNC-84 and that disrupt only migration (6) (Fig. 2F). ANC-1 was still detected at normal levels in the cytoplasm in all unc-84 mutants." | ||||
| Detection_method | Antibody | ||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000041 | ||
| Subcellular_localization | nuclear envelope | ||||
| Paper | WBPaper00005468 | ||||
| Remark | Fig. 2e |
