WormBase Tree Display for Interaction: WBInteraction000556154

WBInteraction000556154 Interaction_type: Regulatory: Change_of_localization
  Interactor: Interactor_overlapping_gene: WBGene00006974 Interactor_type: Trans_regulated
        Expr_pattern: Expr1999
        Transgene: WBTransgene00005109
        Construct: WBCnstr00005086
      WBGene00002047 Interactor_type: Trans_regulator
  Interaction_summary: "We found that in the first cell cycle of icp-1(RNAi) embryos, ZEN-4 initially localized to the expected position. However, ZEN-4 did not persist as it does in wild-type embryos; ZEN-4 disappeared after roughly 1-2 minutes (Figure 7; average 1.7 minutes, n = 7). As ZEN-4 and CYK-4 are each required for central spindle assembly, we conclude that, in the first division of icp-1(RNAi) embryos, the central spindle does not stably assemble, thus contributing to the late defects in cytokinesis"
  Detection_method: Construct
    Reporter_gene: [ZEN-4::GFP]
    Transgene
  Regulation_level: Post_translational
  Regulation_result: Positive_regulate: Life_stage: WBls:0000003
      Subcellular_localization: spindle midzone
  Paper: WBPaper00004389
  Remark: Fig. 7