WormBase Tree Display for Interaction: WBInteraction000549533
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| WBInteraction000549533 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00013090 | Interactor_type | Trans_regulated | |
| WBGene00020760 | Interactor_type | Trans_regulated | |||
| Other_interactor | Pseudomonas aeruginosa PA14 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "Upon exposure to virulent Pseudomonas, wildtype C. elegans rapidly remodel gene expression, with some transcripts rising 200-fold within 4-8 hr (Troemel et al., 2006) (see also Figures 5A-5D). Although infection response genes are upregulated in sams-1 animals fed E. coli, the increase is moderate (2-5 fold, with a few as high as 10-fold) (Figure 1B; Figure S1C). Remarkably, induction of these genes did not occur in sams-1(lof) animals exposed to virulent Pseudomonas (Figures 5A and 5B). This effect did not extend to genes specific to other stresses because the oxidative stress response gene, sod-3, remained unchanged... We found these infection response genes also failed to increase in sams-1(lof) animals exposed to Pseudomonas (Figures 5C and 5D)." | ||||
| Detection_method | RT_PCR | ||||
| Regulation_level | Transcriptional | ||||
| Paper | WBPaper00048490 | ||||
| Remark | Fig. 5c |
