WormBase Tree Display for Interaction: WBInteraction000549001
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| WBInteraction000549001 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003994 | Interactor_type | Trans_regulator | |
| WBGene00003424 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "We found that simultaneous RNAi depletion of the redundantly functioning paralogs pgl-1 and pgl-3 (Kawasaki et al., 2004) caused msp-3 expansion in 20% of worms (supplementary material Fig. S5; Table 1). This expansion was also observed in 18% of worms only fed pgl-1 RNAi, and in 30% only fed glh-1 RNAi. We also observed an expanded msp-3 domain in 18% of glh-4(gk224) glh-1(ok439) double mutants, in 31% of pgl-1(bn101) single mutants and in 20%of pgl-3(bn104) single mutants. Proximal germlines in pgl-1(bn101); pgl-3(bn104) did not show an expansion of the msp-3 domain, but these double mutants contained very severe germline proliferation defects that might have masked this phenotype." | ||||
| Detection_method | In_situ | smFISH | |||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Negative_regulate | Life_stage | WBls:0000041 | ||
| Anatomy_term | WBbt:0005175 | ||||
| Paper | WBPaper00046805 | ||||
| Remark | Table 1, Fig. S5 |
