WormBase Tree Display for Interaction: WBInteraction000541885
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| WBInteraction000541885 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003209 | Interactor_type | Trans_regulator | |
| WBGene00003183 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr2693 | ||||
| Interaction_summary | In wild-type, MEI-1/MEI-2 complex localizes to the spindle and chromosones during meiosis and degrades after meiosis. In mel-26(RNAi) embryos, MEI-GFP accumulated at the forming mitotic spindle. | ||||
| Detection_method | Reporter_gene | [mei-1::gfp], translantional fusion of MEI-1 with GFP. | |||
| Western | anti_GFP antibody | ||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Negative_regulate | Subcellular_localization | forming mitotic spindle | ||
| Interaction_RNAi | WBRNAi00064138 | ||||
| Paper | WBPaper00006054 | ||||
| Remark | Futhermore western blot experiments revealed an increase in MEI-1-GFP levels in mel-26(RNAi) embryo, suggesting that MEI-1 regultion by MEL-26 occurs at the level of protein stability. |
