WormBase Tree Display for Interaction: WBInteraction000541606
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| WBInteraction000541606 | Interaction_type | Regulatory | |||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00000147 | Interactor_type | Trans_regulator | |
| WBGene00000148 | Interactor_type | Trans_regulated | |||
| Interaction_summary | In wild-type 4-cell stage embryos, the APH-2 protein is associated with the surface membranes of all four cells. In aph-1 mutant embryos, the APH-2 protein was mislocalized in all aph-1 mutant embryos examined (n > 200 embryos between the 2-cell and 28-cell stages). In aph-1 mutant embryos, APH-2 was not detectable on the cell surface, and was instead prominent in the cytoplasm of all four cells, where it was concentrated around the nucleus in a pattern characteristic of the endoplasmic reticulum. These results suggest that APH-1 facilitates the translocation of APH-2 to the cell surface. | ||||
| Regulation_result | Negative_regulate | Anatomy_term | WBbt:0005906 | ||
| WBbt:0005994 | |||||
| WBbt:0006873 | |||||
| WBbt:0006876 | |||||
| Paper | WBPaper00005082 | ||||
| Antibody_remark | Anti APH-2 antibody. |
