WormBase Tree Display for Gene: WBGene00000147
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| WBGene00000147 | SMap | S_parent | Sequence | VF36H2L | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | aph-1 | Person_evidence | WBPerson498 | |||||
| Sequence_name | VF36H2L.1 | ||||||||
| Molecular_name | VF36H2L.1 | ||||||||
| VF36H2L.1.1 | |||||||||
| CE16526 | |||||||||
| Other_name | pen-1 | ||||||||
| CELE_VF36H2L.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | aph-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aph | ||||||||
| Allele (29) | |||||||||
| Legacy_information | [C.elegansII] zu123 : maternal effect lethal, no anterior pharynx;resembles Glp-1 embryonic phenotype but no Lag or germ line phenotypes. Maternal rescue complete.OA1: zu147 (weaker allele).[JJ] | ||||||||
| or28 : mutants exhibit a recessive, fully penetrant egg-laying defect; aph-1(or28) is also maternal effect Emb. | |||||||||
| Strain | WBStrain00004780 | ||||||||
| WBStrain00007372 | |||||||||
| WBStrain00007373 | |||||||||
| WBStrain00007374 | |||||||||
| WBStrain00007375 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Contained_in_operon | CEOP1542 | ||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation. | Paper_evidence | WBPaper00005082 | |||||
| WBPaper00005374 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein-macromolecule adaptor activity. Involved in several processes, including cell differentiation; pharynx development; and protein localization to cell surface. Predicted to be located in endoplasmic reticulum. Predicted to be part of gamma-secretase complex. Human ortholog(s) of this gene implicated in coronary artery disease. Is an ortholog of human APH1A (aph-1 homolog A, gamma-secretase subunit) and APH1B (aph-1 homolog B, gamma-secretase subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:24080) | ||||
| Molecular_info | Corresponding_CDS | VF36H2L.1 | |||||||
| Corresponding_transcript | VF36H2L.1.1 | ||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf664684 | ||||||||
| WBsf664685 | |||||||||
| WBsf220056 | |||||||||
| WBsf220057 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern | Expr1013430 | ||||||||
| Expr1030079 | |||||||||
| Expr1158014 | |||||||||
| Expr2009358 | |||||||||
| Expr2027594 | |||||||||
| Drives_construct | WBCnstr00007289 | ||||||||
| WBCnstr00037704 | |||||||||
| Construct_product | WBCnstr00007283 | ||||||||
| WBCnstr00007288 | |||||||||
| WBCnstr00007289 | |||||||||
| WBCnstr00007290 | |||||||||
| WBCnstr00037704 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (106) | |||||||||
| Interaction (62) | |||||||||
| WBProcess | WBbiopr:00000072 | ||||||||
| Map_info | Map | I | Position | 3.6794 | Error | 0.007271 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | VF36H2L | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 2276 | |||||||
| 2277 | |||||||||
| 5072 | |||||||||
| Pos_neg_data | 6815 | ||||||||
| 6816 | |||||||||
| Reference (34) | |||||||||
| Method | Gene |
