WormBase Tree Display for Interaction: WBInteraction000537400
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| WBInteraction000537400 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00013878 | Interactor_type | Effector | |
| WBGene00004978 | Interactor_type | Affected | |||
| Variation_interactor | WBVar00296705 | Interactor_type | Effector | ||
| Interaction_summary | "The UPRmt was induced by allowing worms to develop on spg-7(RNAi) for two days before pathogen exposure. UPRmt pre-activation dramatically reduced the intestinal accumulation of P. aeruginosa expressing GFP (P. aeruginosa-GFP (Fig. 3c, d)). Importantly, P. aeruginosa-GFP accumulated in the intestine of atfs-1(tm4919) worms following spg-7(RNAi) treatment indicating that UPRmt activation promotes pathogen clearance." | ||||
| Throughput | Low_throughput | ||||
| Interaction_RNAi | WBRNAi00110084 | ||||
| Interaction_phenotype | WBPhenotype:0001866 | ||||
| WBProcess | WBbiopr:00000039 | ||||
| Paper | WBPaper00045829 | ||||
| Remark | Fig. 3c, d, Extended Data Figure 5d,e |
