WormBase Tree Display for Interaction: WBInteraction000535499
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| WBInteraction000535499 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006749 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr12889 | ||||
| Transgene | WBTransgene00022990 | ||||
| Antibody | WBAntibody00001277 | ||||
| WBGene00006780 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar02146400 | Interactor_type | Trans_regulator | ||
| Interaction_summary | About 65% of yad21 and 35% of yad26 animals had more UNC-9 puncta at both zone 1 and zone 2, and the length of gap junction zone 1 in those animals was enlarged from 23m to about 25m. Neither yad21 nor yad26 changed the overall expression level of GFP::UNC-9. Loss-of-function mutation in unc-33 or unc-44 decreased the number of UNC-9 particles moving away from gap junctions and induced an imbalance of gap junction dynamics. Similar mis-accumulation of endogenous UNC-9 in unc-44 and unc-33 mutants was observed using the UNC-9 specific antibody. | ||||
| Detection_method | Antibody | ||||
| Reporter_gene | [GFP::UNC-9] | ||||
| Transgene | |||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Negative_regulate | Subcellular_localization | gap junction | ||
| Paper | WBPaper00049389 |
