WormBase Tree Display for Interaction: WBInteraction000534751
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| WBInteraction000534751 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00001840 | Interactor_type | Effector | |
| WBGene00000898 | Interactor_type | Affected | |||
| Variation_interactor | WBVar00143949 | Interactor_type | Affected | ||
| Interaction_summary | Knockdown of hel-1 specifically decreased daf-2(-)-mediated lon- gevity in an RNAi-hypersensitive rrf-3(pk1426) mutant background. We also found that hel-1(gk148684) [hel-1(-)] mutations, which caused a conserved glutamate-to-lysine (E155K) change in the DEAD-box domain, specifically reduced the long lifespan of daf-2(-) mutants without affecting development. The hel-1 mutations decreased the reproductive span of daf-2 mutants but not that of wild-type animals. | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0000039 | ||||
| WBPhenotype:0002169 | |||||
| Paper | WBPaper00047131 |
