WormBase Tree Display for Interaction: WBInteraction000502185
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| WBInteraction000502185 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006742 | Interactor_type | Trans_regulator | |
| WBGene00006779 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr3674 | ||||
| Variation_interactor | WBVar00142938 | Interactor_type | Trans_regulator | ||
| Interaction_summary | Both wild-type and unc-2 mutant nematodes contained similar levels of cellular UNC-43::GFP. However, although wild-type nematodes contained abundant UNC-43::GFP in their neurites, unc-2 mutants contained low neurite levels of the kinase. Interestingly, unc-2 loss-of-function mutants also contained fewer clusters of UNC-43::GFP. | ||||
| Detection_method | Reporter_gene | [unc-43::cfp] translational fusion. | |||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005829 | ||
| Subcellular_localization | UNC-43::CFP protein was detected in neuron cell bodies and out at neurites, where it formed clusters along the ventral nerve cord. | ||||
| Paper | WBPaper00026734 | ||||
| Remark | UNC-2 regulates two different aspects of UNC-43 neurite localization: the amount of UNC-43 that accumulates in the unlocalized neurite pool and the amount of UNC-43 that accumulates in clusters. |
