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WormBase Tree Display for Variation: WBVar00142938

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Name Class

WBVar00142938EvidencePaper_evidenceWBPaper00006005
NamePublic_namee55
Other_name (30)
HGVSgCHROMOSOME_X:g.2723343G>A
Sequence_detailsSMapS_parentSequenceT02C5
Flanking_sequencesagacggcgagccgctaataaaaagttaaaaaagcctcaaaacagcagtctacagaaactg
Mapping_targetT02C5
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00006005
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (14)
LaboratoryCB
StatusLive
AffectsGeneWBGene00006742
Transcript (15)
InteractorWBInteraction000052099
WBInteraction000052101
WBInteraction000501477
WBInteraction000501479
WBInteraction000502185
IsolationMutagenEMS
GeneticsInterpolated_map_positionX-13.8024
Mapping_dataIn_2_point154
3151
In_multi_point (14)
In_pos_neg_data (18)
DescriptionPhenotype (16)
Phenotype_not_observedWBPhenotype:0001182Paper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
RemarkMutants had wild-type fat contentPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentFat content was visualized by Nile red stainingPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
WBPhenotype:0001645Paper_evidenceWBPaper00040284
Curator_confirmedWBPerson2987
RemarkTable S2Paper_evidenceWBPaper00040284
Curator_confirmedWBPerson2987
WBPhenotype:0001660Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
RemarkNo disruption of ASE asymmetry (as seen with lim-6 and gcy-7 reporters)Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Phenotype_assayGenotypeotIs114, otIs6, otIs3Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
WBPhenotype:0001811Paper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
RemarkMutants were susceptible to the fat-reducing effects of exogenously administered serotoninPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentReduced fat content of 5-HT-treated animals was visualized by Nile red staining and confirmed by thin-layer chromatography (TLC) quantitation of total triglycerides extracted from vehicle- and 5-HT-treated worms and by Sudan black fat stainingPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Reference (21)
RemarkResequencing of e55 places the lesion at Q(458) (in isoform T02C5.5b) with flanks of agacggcgagccgctaataaaaagttaaaa & aagcctcaaaacagcagtctacagaaactgPerson_evidenceWBPerson12335
Laboratory_evidenceKG
Following genotyping from the CGC we are updating the flanking sequences to follow both the reported update from 2011 and those now supplied by the CGC. Old flanks [tgttgccattcagttggaaaattcatcaaa aactgaggtaagaataaataatagtgtttt].Person_evidenceWBPerson2207
Curator_confirmedWBPerson1983
MethodSubstitution_allele