WormBase Tree Display for Interaction: WBInteraction000501669
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| WBInteraction000501669 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001257 | Interactor_type | Trans_regulator | |
| WBGene00001609 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr541 | ||||
| Variation_interactor | WBVar00087766 | Interactor_type | Trans_regulator | ||
| Interaction_summary | In wild-type embryos, GLP-1 is not observed at the 1-cell stage and is found in AB descendants by the 4-cell stage. Some 2-cell embryos possess weak GLP-1 staining that also is restricted to AB. After the 4-cell stage, strong GLP-1 staining persists in AB descendants until the 28-cell stage, while weak GLP-1 is detected in membranes between certain P1 descendants beginning at the 8-cell stage (between E and MS and between E and P3). For emb-8(hc69) embryos, 68% (13/19) had a normal distribution of GLP-1. Thirty-two percent (6/19) of the embryos stained for GLP-1 in both AB and P1 descendants at the 4- to 12-cell stages. | ||||
| Regulation_result | Negative_regulate | Life_stage | WBls:0000072 | ||
| WBls:0000008 | |||||
| Anatomy_term | WBbt:0002459 | ||||
| Paper | WBPaper00002654 | ||||
| Antibody_remark | [cgc2045]:glp-1 | ||||
| Remark | All blastomeres of many 4-cell emb-8 embryos had similar sizes and nuclei appeared to be at the same stage of the cell cycle, suggesting that emb-8 embryos may have synchronous and symmetrical early divisions like par mutants. |
