WormBase Tree Display for Gene: WBGene00050875
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| WBGene00050875 | SMap | S_parent | Sequence | ZK1025 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | bah-1 | Paper_evidence | WBPaper00035152 | |||||
| Person_evidence | WBPerson125 | ||||||||
| Sequence_name | ZK1025.7 | ||||||||
| Molecular_name | ZK1025.7 | ||||||||
| ZK1025.7.1 | |||||||||
| CE19334 | |||||||||
| Other_name | CELE_ZK1025.7 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | bah-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 31 Jul 2007 09:27:58 | WBPerson2970 | Event | Created | |||
| 2 | 07 Sep 2009 16:20:54 | WBPerson1847 | Event | Acquires_merge | WBGene00014187 | ||||
| Acquires_merge | WBGene00014187 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bah | ||||||||
| Allele (64) | |||||||||
| Strain | WBStrain00032417 | ||||||||
| WBStrain00004729 | |||||||||
| WBStrain00004755 | |||||||||
| WBStrain00005601 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00104538 | ||||||||
| 00104539 | |||||||||
| 00104540 | |||||||||
| 00104541 | |||||||||
| Ortholog (45) | |||||||||
| Paralog (38) | |||||||||
| Structured_description | Concise_description | bah-1 encodes a protein with a DUF23 domain, a domain found in insects, plants, bacteria and two vertebrates, the frog and the fish, Tetraodon, but absent from mammalian genomes; bah-1 normally functions to contribute to the integrity of the nematode cuticle; bah-1 is also required for the surface characteristics of the elegans cuticle that are required for the binding of bacterial biofilms; bah-1 expression is down-regulated in mutants of the TGF-beta pathway, like daf-7, daf-8 or daf-14, as such, these mutants do not form biofilms, suggesting that the TGF-beta pathway regulates bah-1 and possibly other genes required for biofilm binding; bah-1 is expressed in the seam cells which are part of the cuticle-synthesizing hypodermis. | Paper_evidence | WBPaper00035152 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Sep 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable glycosyltransferase activity. Predicted to be located in membrane. Expressed in seam cell. Used to study bacterial infectious disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00035152 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Mar 2023 00:00:00 | ||||||||
| Disease_relevance | C. elegans is being used as a model system to identify and study the genes required for the formation of bacterial biofilms in the host; the inherent resistance of biofilms to antimicrobial agents like phagocytes, antibiotics etc, are the root cause of chronic bacterial infections; the bah genes in elegans, bah-1, bah-2 and bah-3 are required for infection of elegans by biofilm producing bacteria Yersinia pestis and Yersinia pseudotuberculosis, which bind to the C. elegans surface, predominantly on the head. | Homo sapiens | Paper_evidence | WBPaper00006215 | |||||
| WBPaper00035152 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Sep 2011 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000010 | ||||||||
| Molecular_info | Corresponding_CDS | ZK1025.7 | |||||||
| Corresponding_transcript | ZK1025.7.1 | ||||||||
| Other_sequence | CR08419 | ||||||||
| CRC03784_1 | |||||||||
| Associated_feature | WBsf218537 | ||||||||
| WBsf218538 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00059046 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00082255 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059047 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004903 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004905 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082265 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12811 | ||||||||
| Expr1011822 | |||||||||
| Expr1040381 | |||||||||
| Expr1162477 | |||||||||
| Expr2009528 | |||||||||
| Expr2027765 | |||||||||
| Drives_construct | WBCnstr00022882 | ||||||||
| WBCnstr00022883 | |||||||||
| WBCnstr00023201 | |||||||||
| Construct_product | WBCnstr00022882 | ||||||||
| WBCnstr00022883 | |||||||||
| WBCnstr00023201 | |||||||||
| Microarray_results (13) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (178) | |||||||||
| Map_info | Map | I | Position | 8.73905 | Error | 0.018869 | |||
| Positive | Positive_clone | ZK1025 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Pos_neg_data | 10949 | |||||||
| 10950 | |||||||||
| 10951 | |||||||||
| Reference | WBPaper00029153 | ||||||||
| WBPaper00031925 | |||||||||
| WBPaper00035152 | |||||||||
| WBPaper00039104 | |||||||||
| WBPaper00048269 | |||||||||
| WBPaper00051834 | |||||||||
| WBPaper00065106 | |||||||||
| Method | Gene |
