WormBase Tree Display for Gene: WBGene00044305
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| WBGene00044305 | SMap | S_parent | Sequence | F56H1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | rad-8 | Paper_evidence | WBPaper00040163 | |||||
| Sequence_name | F56H1.6 | ||||||||
| Molecular_name | F56H1.6 | ||||||||
| F56H1.6.1 | |||||||||
| CE45632 | |||||||||
| Other_name | CELE_F56H1.6 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | rad-8 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 21 Apr 2005 09:44:29 | WBPerson1867 | Event | Created | |||
| 2 | 23 Sep 2011 16:44:07 | WBPerson2970 | Event | Acquires_merge | WBGene00004294 | ||||
| Name_change | CGC_name | rad-8 | |||||||
| Acquires_merge | WBGene00004294 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rad | ||||||||
| Reference_allele | WBVar00089079 | ||||||||
| Allele (12) | |||||||||
| Legacy_information | mn163 : hypersensitive to UV not to X irradiation or MMS. Reduced brood size (7% of wildtype) young hermaphrodites lay many inviable eggs. ES1 ME0. NA1. | ||||||||
| [C.elegansII] mn163 : hypersensitive to UV not to X irradiation or MMS. Reduced brood size (7% of wildtype), young hermaphrodites lay many inviable eggs. Hypersensitive to paraquat, high oxygen concentration (lethal at 60%) (see also mev); increased lifespan at 16C.ES1 ME0. NA1. [Hartman and Herman 1982; Ishii et al. 1994; TJ; TK; PH] | |||||||||
| Strain | WBStrain00030672 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | rad-8 encodes a protein with similarity to dehydrogenases/reductases that is orthologous to the human mitochondrial protein RTN4IP1 (reticulon 4 interacting protein 1); rad-8 was identified in screens for loci that when mutated result in abnormal radiation sensitivity; rad-8 mutant animals are hypersensitive to ultraviolet irradiation, methyl viologen (paraquat) treatment, high concentrations of oxygen (50% or greater), and pathogen infection; young adult rad-8 hermaphrodites produce many inviable embryos, but fertility increases as the animals age; rad-8 mutant animals are also long-lived at 16 degrees C, but not at 20 degrees C; a RAD-8::GFP fusion protein is widely expressed and seen in the neurons, pharynx, muscles, and intestine; a RAD-8::GFP fusion protein localizes to mitochondrion; increased oxygen sensitivity displayed by rad-8 mutants can be rescued by overexpression of human RTN4IP1. | Paper_evidence | WBPaper00000565 | |||||
| WBPaper00001740 | |||||||||
| WBPaper00001944 | |||||||||
| WBPaper00002196 | |||||||||
| WBPaper00040163 | |||||||||
| WBPaper00003366 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Apr 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable oxidoreductase activity. Involved in several processes, including defense response to other organism; positive regulation of growth rate; and response to superoxide. Located in mitochondrion. Expressed in several structures, including intestine; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in optic atrophy 10. Is an ortholog of human RTN4IP1 (reticulon 4 interacting protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111434 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18647) | ||||
| Molecular_info | Corresponding_CDS | F56H1.6 | |||||||
| Corresponding_CDS_history | F56H1.6:wp221 | ||||||||
| Corresponding_transcript | F56H1.6.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf643308 | ||||||||
| WBsf656327 | |||||||||
| WBsf217703 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00117135 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern | Expr9670 | ||||||||
| Expr1020437 | |||||||||
| Expr1040219 | |||||||||
| Expr1152520 | |||||||||
| Expr2015243 | |||||||||
| Expr2033477 | |||||||||
| Drives_construct | WBCnstr00014213 | ||||||||
| WBCnstr00023642 | |||||||||
| Construct_product | WBCnstr00014213 | ||||||||
| WBCnstr00023642 | |||||||||
| Microarray_results (14) | |||||||||
| Expression_cluster (68) | |||||||||
| Interaction | WBInteraction000565967 | ||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| Map_info | Positive | Positive_clone | F56H1 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Mapping_data | Multi_point | 372 | |||||||
| 373 | |||||||||
| 3548 | |||||||||
| Interpolated_map_position | I | 0.434476 | |||||||
| Reference (36) | |||||||||
| Method | Gene |
