WormBase Tree Display for Gene: WBGene00022861
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| WBGene00022861 | SMap | S_parent | Sequence | ZK1193 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dve-1 | Person_evidence | WBPerson530 | |||||
| Sequence_name | ZK1193.5 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | CELE_ZK1193.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | dve-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:06 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 16 Feb 2007 14:39:36 | WBPerson2970 | Name_change | CGC_name | dve-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dve | ||||||||
| Allele (100) | |||||||||
| Strain | WBStrain00034074 | ||||||||
| WBStrain00034075 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | dve-1 encodes, by alternative splicing, three proteins with a COMPASS (CMP) domain and two homeodomains; dve-1 interacts with two or more components of the EGF/RAS signallingpathway, and is required for such signalling in vulval development; the CMP domain is found in the N-terminus of SATB-class CUT homeodomain proteins (e.g. human SATB1), and in Drosophila DEFECTIVE PROVENTRICULUS (DVE), to which DVE-1 may be orthologous; both DVE and dve-1 encode two homeodomains which are highly divergent, but homologous between species, and probably derived by intragenic duplication; dve-1 is required for a normally high rate of growth, fluid excretion, and larval viability in in mass RNAi assays. | Paper_evidence | WBPaper00005164 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00027756 | |||||||||
| Person_evidence | WBPerson83 | ||||||||
| Curator_confirmed | WBPerson13481 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Dec 2006 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding activity; and protein-folding chaperone binding activity. Involved in embryo development; mitochondrial unfolded protein response; and regulation of innate immune response. Located in cytosol and nucleus. Part of chromatin and transcription regulator complex. Expressed in several structures, including neurons; rectum; somatic nervous system; tail; and vulva. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Is an ortholog of human SATB1 (SATB homeobox 1) and SATB2 (SATB homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060428 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21637) | ||||
| Molecular_info | Corresponding_CDS | ZK1193.5a | |||||||
| ZK1193.5c | |||||||||
| ZK1193.5d | |||||||||
| ZK1193.5e | |||||||||
| Corresponding_CDS_history | ZK1193.5:wp97 | ||||||||
| ZK1193.5b:wp259 | |||||||||
| ZK1193.5c:wp259 | |||||||||
| Corresponding_transcript | ZK1193.5b | ||||||||
| ZK1193.5a.1 | |||||||||
| ZK1193.5c.1 | |||||||||
| ZK1193.5c.2 | |||||||||
| ZK1193.5d.1 | |||||||||
| ZK1193.5d.2 | |||||||||
| ZK1193.5d.3 | |||||||||
| ZK1193.5d.4 | |||||||||
| ZK1193.5d.5 | |||||||||
| ZK1193.5e.1 | |||||||||
| Other_sequence (205) | |||||||||
| Associated_feature (28) | |||||||||
| Transcription_factor | WBTranscriptionFactor000282 | ||||||||
| Experimental_info | RNAi_result (56) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00003589 | ||||||||
| WBCnstr00005168 | |||||||||
| WBCnstr00005169 | |||||||||
| WBCnstr00012902 | |||||||||
| WBCnstr00015223 | |||||||||
| WBCnstr00023913 | |||||||||
| Construct_product | WBCnstr00005168 | ||||||||
| WBCnstr00005169 | |||||||||
| WBCnstr00016565 | |||||||||
| WBCnstr00016795 | |||||||||
| WBCnstr00023913 | |||||||||
| Regulate_expr_cluster | WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi) | ||||||||
| WBPaper00060084:DVE-1_interacting_protein_control | |||||||||
| Antibody | WBAntibody00001315 | ||||||||
| WBAntibody00002911 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (177) | |||||||||
| Interaction (185) | |||||||||
| WBProcess | WBbiopr:00000077 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | X | Position | -19.8977 | Error | 0.032426 | |||
| Positive | Positive_clone | ZK1193 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (42) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
