WormBase Tree Display for Gene: WBGene00022500
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WBGene00022500 | Evidence | Paper_evidence | WBPaper00013452 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | ZC8 | ||||||
Identity | Version | 2 | |||||||
Name | CGC_name | lfi-1 | Person_evidence | WBPerson732 | |||||
Sequence_name | ZC8.4 | ||||||||
Molecular_name (21) | |||||||||
Other_name | CELE_ZC8.4 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lfi-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 04 Jun 2004 10:29:58 | WBPerson1971 | Name_change | CGC_name | lfi-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lfi | ||||||||
Allele (252) | |||||||||
Strain | WBStrain00032313 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00023076 | ||||||||
00023077 | |||||||||
Ortholog (43) | |||||||||
Paralog | WBGene00018051 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | lfi-1 encodes, by alternative splicing, at least four isoforms of alarge coiled-coil protein paralogous to F35D11.11, and possiblyorthologous to rootletin (the structural protein comprising ciliaryrootlets); LFI-1 is also homologous to the Parascaris univalens MitoticAntigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known. | Paper_evidence | WBPaper00024244 | |||||
WBPaper00029004 | |||||||||
WBPaper00029016 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 07 Feb 2007 00:00:00 | ||||||||
Automated_description | Located in kinetochore microtubule and nucleus. Is an ortholog of human CROCC (ciliary rootlet coiled-coil, rootletin). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | EFO:0009151 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1859) | ||||
Molecular_info | Corresponding_CDS | ZC8.4a | |||||||
ZC8.4d | |||||||||
ZC8.4e | |||||||||
ZC8.4f | |||||||||
ZC8.4g | |||||||||
ZC8.4h | |||||||||
Corresponding_CDS_history | ZC8.4b:wp145 | ||||||||
ZC8.4b:wp272 | |||||||||
ZC8.4c:wp145 | |||||||||
ZC8.4d:wp272 | |||||||||
ZC8.4e:wp272 | |||||||||
Corresponding_transcript | ZC8.4a.1 | ||||||||
ZC8.4a.2 | |||||||||
ZC8.4a.3 | |||||||||
ZC8.4a.4 | |||||||||
ZC8.4d.1 | |||||||||
ZC8.4e.1 | |||||||||
ZC8.4f.1 | |||||||||
ZC8.4g.1 | |||||||||
ZC8.4h.1 | |||||||||
Other_sequence (219) | |||||||||
Associated_feature | WBsf648060 | ||||||||
WBsf648061 | |||||||||
WBsf978486 | |||||||||
WBsf1005147 | |||||||||
WBsf1005148 | |||||||||
WBsf1022896 | |||||||||
WBsf235646 | |||||||||
WBsf235647 | |||||||||
WBsf235648 | |||||||||
Transcription_factor | WBTranscriptionFactor000405 | ||||||||
Experimental_info (8) | |||||||||
Map_info | Map | X | Position | -6.19862 | Error | 0.000328 | |||
Positive | Positive_clone | ZC8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference | WBPaper00010599 | ||||||||
WBPaper00018632 | |||||||||
WBPaper00023417 | |||||||||
WBPaper00024244 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00055090 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |