WormBase Tree Display for Gene: WBGene00022154
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| WBGene00022154 | SMap | S_parent | Sequence | Y71G12B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | drag-1 | Person_evidence | WBPerson1659 | |||||
| Sequence_name | Y71G12B.16 | ||||||||
| Molecular_name | Y71G12B.16 | ||||||||
| Y71G12B.16.1 | |||||||||
| CE45612 | |||||||||
| Other_name | CELE_Y71G12B.16 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | drag-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Apr 2010 10:27:11 | WBPerson2970 | Name_change | CGC_name | drag-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | drag | ||||||||
| Allele (106) | |||||||||
| Strain | WBStrain00001577 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | drag-1 encodes the C. elegans homolog of a putative GPI-anchor protein of the RGM family, a membrane associated protein that functions as co-receptor in the the Sma/Mab pathway; drag-1 mutants exhibit a subset of phenotypes seen in mutants in the Sma/Mab pathway like smaller than wildtype worm phenotype throughout the larval development, the males could mate and have no male tail patterning defects; drag-1 genetically interacts with daf-7 and daf-1 mutants in dauer pathway; drag-1 likely acts upstream of lon-1, but in parallel to lon-2 and dbl-1 suggesting that it is functioning at the ligands-receptor level in the Sma/Mab pathway to regulate body size; Drag-1 functions in the same cells as the Sma-9 and Sma/Mab receptors and SMAD proteins to regulate body size; DRAG-1 is not only present but also functions at the cell membrane; DRAG-1 is a positive regulator of the sma/Mab pathway; drag-1p::gfp is expressed in pharyngeal, hypodermal and intestinal cells as like sma-6 in hermaphrodites, but not in male tail cells. | Paper_evidence | WBPaper00036372 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 24 May 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable coreceptor activity. Involved in several processes, including mesodermal cell fate specification; regulation of BMP signaling pathway; and regulation of dauer larval development. Located in plasma membrane. Part of receptor complex. Expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in hemochromatosis type 2A and multiple sclerosis. Is an ortholog of human HJV (hemojuvelin BMP co-receptor) and RGMA (repulsive guidance molecule BMP co-receptor a). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30308) | ||||
| DOID:2352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4887) | ||||||
| DOID:0111027 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4887) | ||||||
| Molecular_info | Corresponding_CDS | Y71G12B.16 | |||||||
| Corresponding_CDS_history | Y71G12B.16:wp124 | ||||||||
| Y71G12B.16:wp155 | |||||||||
| Y71G12B.16:wp213 | |||||||||
| Y71G12B.16:wp222 | |||||||||
| Corresponding_transcript | Y71G12B.16.1 | ||||||||
| Other_sequence | HC08580 | ||||||||
| AS13688 | |||||||||
| BF482110.1 | |||||||||
| Acan_isotig19977 | |||||||||
| HC02243 | |||||||||
| PPC13396_1 | |||||||||
| EL888975.1 | |||||||||
| Associated_feature | WBsf717457 | ||||||||
| WBsf982734 | |||||||||
| WBsf982735 | |||||||||
| WBsf1009237 | |||||||||
| WBsf1009238 | |||||||||
| WBsf217234 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00004820 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00058202 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1741 | ||||||||
| Expr7110 | |||||||||
| Expr9068 | |||||||||
| Expr9069 | |||||||||
| Expr1021841 | |||||||||
| Expr1039760 | |||||||||
| Expr1161619 | |||||||||
| Expr2011081 | |||||||||
| Expr2029318 | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (14) | |||||||||
| Antibody | WBAntibody00003004 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (65) | |||||||||
| Interaction | WBInteraction000555255 | ||||||||
| WBInteraction000555256 | |||||||||
| WBInteraction000555257 | |||||||||
| WBInteraction000555258 | |||||||||
| Map_info | Map | I | Position | -13.4448 | Error | 0.036264 | |||
| Positive | Positive_clone | Y71G12B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00036372 | ||||||||
| WBPaper00037003 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00043609 | |||||||||
| WBPaper00044134 | |||||||||
| WBPaper00052244 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062127 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
