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WormBase Tree Display for Gene: WBGene00022154

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Name Class

WBGene00022154SMapS_parentSequenceY71G12B
IdentityVersion2
NameCGC_namedrag-1Person_evidenceWBPerson1659
Sequence_nameY71G12B.16
Molecular_nameY71G12B.16
Y71G12B.16.1
CE45612
Other_nameCELE_Y71G12B.16Accession_evidenceNDBBX284601
Public_namedrag-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:05WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
230 Apr 2010 10:27:11WBPerson2970Name_changeCGC_namedrag-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdrag
Allele (106)
StrainWBStrain00001577
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (40)
Structured_descriptionConcise_descriptiondrag-1 encodes the C. elegans homolog of a putative GPI-anchor protein of the RGM family, a membrane associated protein that functions as co-receptor in the the Sma/Mab pathway; drag-1 mutants exhibit a subset of phenotypes seen in mutants in the Sma/Mab pathway like smaller than wildtype worm phenotype throughout the larval development, the males could mate and have no male tail patterning defects; drag-1 genetically interacts with daf-7 and daf-1 mutants in dauer pathway; drag-1 likely acts upstream of lon-1, but in parallel to lon-2 and dbl-1 suggesting that it is functioning at the ligands-receptor level in the Sma/Mab pathway to regulate body size; Drag-1 functions in the same cells as the Sma-9 and Sma/Mab receptors and SMAD proteins to regulate body size; DRAG-1 is not only present but also functions at the cell membrane; DRAG-1 is a positive regulator of the sma/Mab pathway; drag-1p::gfp is expressed in pharyngeal, hypodermal and intestinal cells as like sma-6 in hermaphrodites, but not in male tail cells.Paper_evidenceWBPaper00036372
Curator_confirmedWBPerson12884
Date_last_updated24 May 2011 00:00:00
Automated_descriptionPredicted to enable coreceptor activity. Involved in several processes, including mesodermal cell fate specification; regulation of BMP signaling pathway; and regulation of dauer larval development. Located in plasma membrane. Part of receptor complex. Expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in hemochromatosis type 2A and multiple sclerosis. Is an ortholog of human HJV (hemojuvelin BMP co-receptor) and RGMA (repulsive guidance molecule BMP co-receptor a).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:2377Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:30308)
DOID:2352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4887)
DOID:0111027Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4887)
Molecular_infoCorresponding_CDSY71G12B.16
Corresponding_CDS_historyY71G12B.16:wp124
Y71G12B.16:wp155
Y71G12B.16:wp213
Y71G12B.16:wp222
Corresponding_transcriptY71G12B.16.1
Other_sequenceHC08580
AS13688
BF482110.1
Acan_isotig19977
HC02243
PPC13396_1
EL888975.1
Associated_featureWBsf717457
WBsf982734
WBsf982735
WBsf1009237
WBsf1009238
WBsf217234
Experimental_infoRNAi_resultWBRNAi00004820Inferred_automaticallyRNAi_primary
WBRNAi00058202Inferred_automaticallyRNAi_primary
Expr_patternChronogram1741
Expr7110
Expr9068
Expr9069
Expr1021841
Expr1039760
Expr1161619
Expr2011081
Expr2029318
Drives_construct (12)
Construct_product (14)
AntibodyWBAntibody00003004
Microarray_results (17)
Expression_clusterWBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00040560:hpl-2_embryo_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L4
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051558:aging_regulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061341:28C_24h_upregulated
WBPaper00061357:mett-10(ok2204)_upregulated_OP50
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:176662_at-Y53F4B.16
WBPaper00061653:alh-4(hj221)_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064716:paraquat_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065841:102_0
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4489_group_14
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
InteractionWBInteraction000555255
WBInteraction000555256
WBInteraction000555257
WBInteraction000555258
Map_infoMapIPosition-13.4448Error0.036264
PositivePositive_cloneY71G12BInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00036372
WBPaper00037003
WBPaper00038491
WBPaper00043609
WBPaper00044134
WBPaper00052244
WBPaper00055090
WBPaper00062127
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene