WormBase Tree Display for Gene: WBGene00021697

WBGene00021697 SMap: S_parent: Sequence: Y48G9A
  Identity: Version: 3
    Name: CGC_name: gcn-1 Person_evidence: WBPerson644
      Sequence_name: Y48G9A.3
      Molecular_name: Y48G9A.3
        Y48G9A.3.1
        CE54096
      Other_name: Y48G9A.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.l Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.m Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.n Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.o Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y48G9A.3 Accession_evidence: NDB BX284603
      Public_name: gcn-1
    DB_info: Database: AceView gene 3D249
        WormQTL gene WBGene00021697
        WormFlux gene WBGene00021697
        NDB locus_tag CELE_Y48G9A.3
        Panther gene CAEEL|WormBase=WBGene00021697|UniProtKB=B3CJ34
          family PTHR23346
        NCBI gene 190051
        RefSeq protein NM_001381763.1
        TREEFAM TREEFAM_ID TF105398
        TrEMBL UniProtAcc B3CJ34
        UniProt_GCRP UniProtAcc B3CJ34
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:04 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 15 Sep 2008 11:24:05 WBPerson2970 Name_change: CGC_name: gcn-1
        3 07 May 2008 11:46:03 WBPerson1867 Event: Acquires_merge: WBGene00021695
      Acquires_merge: WBGene00021695
        WBGene00021696
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gcn
    Allele (932)
    Strain: WBStrain00034488
      WBStrain00027623
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP3834
    Ortholog (53)
    Paralog: WBGene00008422 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010364 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: gcn-1 encodes the C. elegans ortholog of the S. cerevisiae ribosome-associated protein Gcn1p; GCN-1, along with ABCF-3, is required for maintaining the steady-state levels of phosphorylated eIF2alpha, and thus for the translational control of a number of mRNAs; GCN-1 activity is required, in parallel to, or downstream of, the canonical apoptotic pathway, for apoptotic cell death of most somatic cells and germ cells in response to ionizing radiation; in addition, GCN-1 is required for normal growth rates, and spatial organization of germ cells in the gonad; as in S. cerevisiae, GCN-1 physically interacts with ABCF-3, the C. elegans ortholog of budding yeast Gcn20p, and GCN-1 and ABCF-3 are each required for the other's stability; a gcn-1::gfp promoter fusion is expressed in most cells, including germ cells, throughout development. Paper_evidence: WBPaper00045601
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Aug 2014 00:00:00
      Automated_description: Predicted to enable protein kinase regulator activity. Involved in positive regulation of peptidyl-serine phosphorylation; regulation of apoptotic process; and regulation of translation. Acts upstream of with a positive effect on positive regulation of gene expression. Acts upstream of or within with a negative effect on negative regulation of translation. Predicted to be located in cytosolic ribosome. Expressed in several structures, including body wall musculature; head neurons; hermaphrodite gonad; intestinal cell; and pharyngeal neurons. Is an ortholog of human GCN1 (GCN1 activator of EIF2AK4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y48G9A.3
    Corresponding_CDS_history: Y48G9A.3:wp150
      Y48G9A.3:wp191
      Y48G9A.3:wp237
      Y48G9A.3:wp275
    Corresponding_transcript: Y48G9A.3.1
    Other_sequence (91)
    Associated_feature (40)
  Experimental_info: RNAi_result: WBRNAi00056982 Inferred_automatically: RNAi_primary
      WBRNAi00056977 Inferred_automatically: RNAi_primary
      WBRNAi00037280 Inferred_automatically: RNAi_primary
      WBRNAi00093045 Inferred_automatically: RNAi_primary
      WBRNAi00077044 Inferred_automatically: RNAi_primary
      WBRNAi00037275 Inferred_automatically: RNAi_primary
      WBRNAi00056981 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11922
      Expr11923
      Expr1022586
      Expr1039504
      Expr1160428
      Expr2011967
      Expr2030204
    Drives_construct: WBCnstr00019541
    Construct_product: WBCnstr00019540
    Regulate_expr_cluster: WBPaper00065578:gcn-1(nc40)_downregulated
      WBPaper00065578:gcn-1(nc40)_upregulated
    Antibody: WBAntibody00002554
    Microarray_results (42)
    Expression_cluster (163)
    Interaction (150)
  Map_info: Map: III Position: -15.0586 Error: 0.039572
    Positive: Positive_clone: Y48G9A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene