WormBase Tree Display for Gene: WBGene00021416
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| WBGene00021416 | SMap | S_parent | Sequence | Y38F2AL | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | mksr-2 | Paper_evidence | WBPaper00032899 | |||||
| Person_evidence | WBPerson2136 | ||||||||
| WBPerson711 | |||||||||
| Sequence_name | Y38F2AL.2 | ||||||||
| Molecular_name | Y38F2AL.2 | ||||||||
| Y38F2AL.2.1 | |||||||||
| CE21622 | |||||||||
| Other_name | tza-1 | ||||||||
| Y38F2AL.f | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y38F2AL.2 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | mksr-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 08 Jun 2007 15:14:26 | WBPerson2970 | Name_change | CGC_name | tza-1 | ||||
| 3 | 19 Oct 2009 17:02:44 | WBPerson9133 | Name_change | CGC_name | mksr-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mksr | ||||||||
| Allele (61) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00019364 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020100 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mkrs-2 encodes an ortholog of human B9D2 (OMIM:611951), paralogous to MKRS-1 and MKS-1; MKRS-2 is required for fully normal foraging behavior, and is redundantly required with NPH-4 for roughly normal foraging, and with both NPH-1 and NPH-4 for cilia formation; MKRS-2 is expressed in most ciliated cells, including amphid, phasmid, and labial-quadrant neurons, in a DAF-19-dependent manner; MKRS-2 forms a complex with MKRS-1 and MKS-1 at the base of cilia, and is coexpressed with these proteins in ciliated sensory neurons; MKRS-2 protein is required for proper localization of MKRS-1 and MKS-1 to the transition zone, and binds MKRS-1 in two-hybrid assays. | Paper_evidence | WBPaper00026601 | |||||
| WBPaper00031596 | |||||||||
| WBPaper00032899 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Oct 2009 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including determination of adult lifespan; larval foraging behavior; and non-motile cilium assembly. Located in ciliary basal body; ciliary transition zone; and dendrite terminus. Expressed in neurons. Used to study Joubert syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome. Is an ortholog of human B9D2 (B9 domain containing 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050777 | Homo sapiens | Paper_evidence | WBPaper00060708 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 May 2022 00:00:00 | ||||||||
| DOID:0060340 | |||||||||
| Potential_model | DOID:0050777 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28636) | |||||
| Models_disease_asserted | WBDOannot00000137 | ||||||||
| WBDOannot00001195 | |||||||||
| Molecular_info | Corresponding_CDS | Y38F2AL.2 | |||||||
| Corresponding_transcript | Y38F2AL.2.1 | ||||||||
| Other_sequence | GRC01626_1 | ||||||||
| GR12635 | |||||||||
| JI182061.1 | |||||||||
| Associated_feature | WBsf047478 | ||||||||
| WBsf047505 | |||||||||
| WBsf667629 | |||||||||
| WBsf667771 | |||||||||
| WBsf995657 | |||||||||
| WBsf1016883 | |||||||||
| WBsf229802 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00036859 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056042 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3726 | ||||||||
| Expr8174 | |||||||||
| Expr8531 | |||||||||
| Expr10104 | |||||||||
| Expr16112 | |||||||||
| Expr1019578 | |||||||||
| Expr1159565 | |||||||||
| Expr2013588 | |||||||||
| Expr2031821 | |||||||||
| Drives_construct | WBCnstr00007463 | ||||||||
| WBCnstr00007464 | |||||||||
| WBCnstr00011630 | |||||||||
| WBCnstr00013159 | |||||||||
| WBCnstr00020667 | |||||||||
| Construct_product | WBCnstr00020667 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction | WBInteraction000032179 | ||||||||
| WBInteraction000384732 | |||||||||
| WBInteraction000503538 | |||||||||
| WBInteraction000507325 | |||||||||
| WBInteraction000507326 | |||||||||
| WBInteraction000507327 | |||||||||
| WBInteraction000513976 | |||||||||
| WBInteraction000548384 | |||||||||
| WBInteraction000551361 | |||||||||
| WBInteraction000556760 | |||||||||
| Map_info | Map | IV | Position | -8.28755 | Error | 0.046305 | |||
| Positive | Positive_clone | Y38F2AL | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
