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WormBase Tree Display for Gene: WBGene00020842

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Name Class

WBGene00020842SMapS_parentSequenceT27A3
IdentityVersion4
NameCGC_namenmrk-1Person_evidenceWBPerson1983
Sequence_nameT27A3.6
Molecular_nameT27A3.6
T27A3.6.1
CE14227
Other_namemoc-4Paper_evidenceWBPaper00056452
CELE_T27A3.6Accession_evidenceNDBBX284601
Public_namenmrk-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:03WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
203 Apr 2017 10:56:14WBPerson2970Name_changeCGC_namenmrk-1
312 Aug 2019 12:44:14WBPerson1983Name_changeOther_namemoc-4
411 Sep 2019 12:48:59WBPerson1983Name_changeCGC_namenmrk-1
Other_namemoc-4
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnmrk
Allele (17)
StrainWBStrain00032639
RNASeq_FPKM (74)
GO_annotation (13)
Contained_in_operonCEOP1300
Ortholog (34)
Structured_descriptionConcise_descriptionT27A3.6 is orthologous to the human gene Molybdenum cofactor synthesis gene 2 (MOCS2), which encodes molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B, which dimerize to form molybdopterin synthase.Paper_evidenceWBPaper00038491
Curator_confirmedWBPerson324
Date_last_updated26 Jun 2012 00:00:00
Automated_descriptionPredicted to enable molybdopterin synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be located in cytosol. Predicted to be part of molybdopterin synthase complex. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Is an ortholog of human MOCS2 (molybdenum cofactor synthesis 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111163Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7193)
Disease_relevanceMutations in the human gene Molybdenum cofactor synthesis gene 2 (MOCS2; orthologous to elegans T27A3.6), are associated with Molybdenum cofactor deficiency, type B, which is an autosomal recessive disease where there is a loss of all molybdoenzyme activities, characterized by neurological damage, seizures and early childhood death.Homo sapiensAccession_evidenceOMIM252150
603708
Curator_confirmedWBPerson324
Date_last_updated26 Jun 2012 00:00:00
Molecular_infoCorresponding_CDST27A3.6
Corresponding_transcriptT27A3.6.1
Other_sequenceCBC15288_1
CR05650
CRC00288_1
Associated_featureWBsf649219
WBsf219542
Experimental_infoRNAi_resultWBRNAi00054263Inferred_automaticallyRNAi_primary
WBRNAi00054264Inferred_automaticallyRNAi_primary
WBRNAi00036016Inferred_automaticallyRNAi_primary
WBRNAi00004319Inferred_automaticallyRNAi_primary
WBRNAi00076715Inferred_automaticallyRNAi_primary
WBRNAi00103547Inferred_automaticallyRNAi_primary
WBRNAi00116636Inferred_automaticallyRNAi_primary
Expr_patternExpr1012188
Expr1039085
Expr1157811
Expr2014334
Expr2032575
Drives_constructWBCnstr00024844
Construct_productWBCnstr00024844
Microarray_results (21)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050015:ifg-1(RNAi)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053321:PGCs_enriched_NuGen
WBPaper00053810:clk-1(qm30)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060661:sensory-neuron_depleted
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061340:AMso_parent
WBPaper00061340:CEPsh
WBPaper00061340:Intestinal_and_rectal_muscle
WBPaper00061340:Parent_of_K_Kprime
WBPaper00061340:Pharyngeal_marginal_cell
WBPaper00061527:lpd-2-EEED8.16
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062590:Aging_upregulated_coelomocyte
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064494:postdauer_upregulated_AWA
WBPaper00064532:pals-22(jy3)_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065841:79_2
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00032165:differentially_expressed_with_age_medoid_5
WBPaper00034739:N2moreDR1350
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Cadmium_regulated
WBPaper00036130:mir-243_down_regulated
WBPaper00036286:Pattern_F
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00044091:Bpseudomallei_repressed_12h
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045263:ProLongevity-mtROS_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_allantoin_upregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MD_pd(23_min)
[cgc5767]:expression_class_SM
[cgc5767]:expression_class_SMD
Interaction (55)
Map_infoMapIPosition0.784315
PositivePositive_cloneT27A3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00038491
WBPaper00051761
WBPaper00055090
WBPaper00056452
WBPaper00064339
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene